MAST - Motif Alignment and Search Tool
MAST version 3.0 (Release date: 2004/08/18 09:07:01)
For further information on how to interpret these results or to get
a copy of the MAST software please access http://meme.sdsc.edu.
REFERENCE
If you use this program in your research, please cite:
Timothy L. Bailey and Michael Gribskov,
"Combining evidence using p-values: application to sequence homology
searches", Bioinformatics, 14(48-54), 1998.
DATABASE AND MOTIFS
DATABASE ../../Data_sets/Fickett/fickett.data (nucleotide)
Last updated on Tue Jun 7 11:32:17 2005
Database contains 46 sequences, 15334 residues
Scores for positive and reverse complement strands are combined.
MOTIFS ../MEME/meme_text_fickett_data_original_anr_15mtfs_8-12_6minsites_revcomp.txt (nucleotide)
MOTIF WIDTH BEST POSSIBLE MATCH
----- ----- -------------------
1 11 CTAAAAATAGC
2 11 AGGGGAGGGGG
3 12 AAAAAAAAGGAA
4 8 AAATAAAT
5 8 AGCAACAG
6 11 AGTGTGTATGT
7 11 CAGAAAGCTGG
8 12 CTCCTTGAGCCA
10 12 CACTCAGTGCCC
11 11 GCTCCCTGGCT
12 8 TTCTCTGA
13 12 AGAGATGGGAGG
14 11 CCTCCCATCCT
15 8 TTCCTGGG
PAIRWISE MOTIF CORRELATIONS:
MOTIF 1 2 3 4 5 6 7 8 10 11 12 13 14
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
2 0.28
3 0.50 0.42
4 0.37 0.13 0.40
5 0.22 0.31 0.32 0.36
6 0.24 0.37 0.39 0.16 0.21
7 0.24 0.29 0.26 0.45 0.38 0.18
8 0.13 0.16 0.08 0.19 0.43 0.14 0.33
10 0.15 0.17 -0.00 0.15 0.28 0.24 0.36 0.49
11 0.11 0.24 0.02 0.19 0.25 0.15 0.27 0.29 0.23
12 0.27 0.17 0.12 0.14 0.23 0.28 0.35 0.40 0.19 0.56
13 0.45 0.51 0.45 0.43 0.35 0.19 0.28 0.17 0.46 0.10 0.23
14 0.14 0.04 0.02 0.22 0.28 0.09 0.34 0.44 0.13 0.38 0.43 0.43
15 0.16 0.30 0.07 0.18 0.19 0.31 0.36 0.36 0.44 0.42 0.51 0.47 0.25
Correlations above 0.60 may cause some combined p-values and
E-values to be underestimates.
Removed motif 9 because they have correlation > 0.60
with the remaining motifs.
Random model letter frequencies (from non-redundant database):
A 0.281 C 0.222 G 0.229 T 0.267
SECTION I: HIGH-SCORING SEQUENCES
- Each of the following 44 sequences has E-value less than 10.
- The E-value of a sequence is the expected number of sequences
in a random database of the same size that would match the motifs as
well as the sequence does and is equal to the combined p-value of the
sequence times the number of sequences in the database.
- The combined p-value of a sequence measures the strength of the
match of the sequence to all the motifs and is calculated by
- finding the score of the single best match of each motif
to the sequence (best matches may overlap),
- calculating the sequence p-value of each score,
- forming the product of the p-values,
- taking the p-value of the product.
- The sequence p-value of a score is defined as the
probability of a random sequence of the same length containing
some match with as good or better a score.
- The score for the match of a position in a sequence to a motif
is computed by by summing the appropriate entry from each column of
the position-dependent scoring matrix that represents the motif.
- Sequences shorter than one or more of the motifs are skipped.
- The table is sorted by increasing E-value.
| Links | Sequence Name | Description | E-value | Length
|
|---|
|
| neurofilament
| light chain s70309 (1150-...
| 3.2e-12
| 1029
|
|
| Actin,
| alpha cardiac promoter -4...
| 2.2e-10
| 553
|
|
| MLc1A
| aka MLc1emb x58851 chr17:...
| 8e-08
| 650
|
|
| sarcomeric
| mitochondrial creatine ki...
| 5.6e-07
| 926
|
|
| MLc1/3_3f
| promoter (-550 to +15) ch...
| 6.5e-07
| 566
|
|
| cardiac
| alpha-MHc x05632/m25162 c...
| 1.4e-06
| 386
|
|
| bin1
| 1275...2162 u83999 (-775....
| 6.2e-06
| 886
|
|
| mhc_b
| upstream enhancer 980...1...
| 1.7e-05
| 268
|
|
| ant1
| promoter -674...+42 J0498...
| 2.1e-05
| 716
|
|
| enolase_b
| intronic enhancer 1371..1...
| 4.2e-05
| 134
|
|
| cytochrome
| oxidase VIa -280...+17 (4...
| 4.6e-05
| 300
|
|
| mlc-2
| Z15030 (1080-1238) chr12:...
| 5.4e-05
| 158
|
|
| myogenin
| (myf4) promoter -211 to +...
| 7e-05
| 286
|
|
| Na-K
| atPase alpha 2 -360...+60...
| 8.9e-05
| 420
|
|
| Desmin_enhancer,
| -973 to -848 m63391 chr2:...
| 0.00012
| 126
|
|
| aB
| crystallin -661...+10 M28...
| 0.00014
| 670
|
|
| myo-D
| distal enhancer approx -2...
| 0.00044
| 258
|
|
| McK_pro
| 5' promoter m21487chr19:5...
| 0.00049
| 718
|
|
| aMPD3
| promoter 1b -14...+310 U2...
| 0.00086
| 327
|
|
| tnI_prom
| slow promoter, -95 to +12...
| 0.00099
| 107
|
|
| tnI_up
| slow upstream enhancer, -...
| 0.0011
| 171
|
|
| AchR_gamma
| -404...-33 Z79612 chr2:24...
| 0.0014
| 389
|
|
| myosin_b
| heavy chain chr14:2037826...
| 0.0014
| 101
|
|
| tnc
| slow/cardiac first intron...
| 0.0022
| 310
|
|
| sm22-alpha
| -140...+1 u73638 (26771.....
| 0.0036
| 190
|
|
| acetylcholinesterase
| gene (approx -180 to +60)...
| 0.0046
| 240
|
|
| myoglobin
| -373...+7 m10090 (1520......
| 0.0047
| 373
|
|
| ryanodine
| receptor u48449 (1811..23...
| 0.0057
| 537
|
|
| aldolase-a
| pM x12447 -235...27 (1526...
| 0.0064
| 278
|
|
| atrial
| natriuretic factor -134.....
| 0.015
| 228
|
|
| tnI_frst_int
| slow first intron enhance...
| 0.019
| 197
|
|
| PgaM-M
| m55673 (1640...1825) chr7...
| 0.037
| 190
|
|
| ventrical/slow
| mlc-1 -312...+10 m76408 (...
| 0.043
| 313
|
|
| McK_enh
| 5' enhancer m21487chr19:5...
| 0.049
| 207
|
|
| AchR_epsilon
| z84811 chr17:5372028-5372...
| 0.1
| 284
|
|
| AchR_delta,
| z79611 chr2:243760886-243...
| 0.11
| 170
|
|
| dystrophin_intron
| enhancer u93356 (1...195)...
| 0.2
| 195
|
|
| Desmin_promoter
| -228 to +75 m63391chr2:22...
| 0.28
| 303
|
|
| dystrophin_promoter
| -140...+20 m32058 (740......
| 0.35
| 161
|
|
| retinoblastoma
| -207...-1 x16439 (695...9...
| 0.37
| 206
|
|
| skeletal
| alpha-actin gene. M20543 ...
| 0.42
| 150
|
|
| MLc1/3
| 3' enhancer, typed in fro...
| 0.58
| 127
|
|
| glut4
| enhancer, m61126chr17:786...
| 1.2
| 61
|
|
| AChR_beta
| promoter Z79610 chr17:809...
| 1.4
| 180
|
SECTION II: MOTIF DIAGRAMS
- The ordering and spacing of all non-overlapping motif occurrences
are shown for each high-scoring sequence listed in Section I.
- A motif occurrence is defined as a position in the sequence whose
match to the motif has POSITION p-value less than 0.0001.
- The POSITION p-value of a match is the probability of
a single random subsequence of the length of the motif
scoring at least as well as the observed match.
- For each sequence, all motif occurrences are shown unless there
are overlaps. In that case, a motif occurrence is shown only if its
p-value is less than the product of the p-values of the other
(lower-numbered) motif occurrences that it overlaps.
- The table also shows the E-value of each sequence.
- Spacers and motif occurences are indicated by
- occurrence of motif `n' with p-value less than 0.0001.
A minus sign indicates that the occurrence is on the
reverse complement strand.
- Sequences longer than 1000 are not shown to scale and are indicated by thicker lines.
| Links | Name | Expect | Motifs
|
|---|
|
| neurofilament
| 3.2e-12
|
| -7
|
| -11
|
| -6
|
| +6
|
| +6
|
| +3
| +4
|
| +3
|
| +7
|
| -4
|
| +3
|
| -10
|
| +7
|
| -14
|
| +3
|
| -12
|
| -8
|
| +14
|
| -13
|
| -13
|
|
|
|
|
| Actin,
| 2.2e-10
|
| -5
|
| -7
|
| -14
|
| -11
|
| +2
|
| -2
|
| -2
|
| -2
|
| +11
|
| -2
|
| -2
|
| +8
|
| +10
|
|
|
|
|
| MLc1A
| 8e-08
|
| +15
|
| +13
|
| -5
|
| +11
|
| -10
|
| +1
|
| -2
|
| +11
|
| +2
|
| -5
|
| -2
|
| +2
|
| -13
|
|
|
|
|
| sarcomeric
| 5.6e-07
|
| +3
|
| -1
|
| -12
|
| +15
| -2
|
| +12
|
| -1
|
| -1
|
| +7
|
| -14
|
| -2
|
| +8
|
| +8
|
| +13
|
| +14
|
| -12
|
|
|
|
|
| MLc1/3_3f
| 6.5e-07
|
| +12
|
| -12
|
| -13
|
| +1
|
| +7
|
| -7
|
| +3
|
| -11
|
| +10
|
|
|
|
|
| cardiac
| 1.4e-06
|
| -6
|
| -14
|
| -7
|
| +2
|
| +1
|
| -11
|
| +2
|
| +2
|
| +2
|
|
|
|
|
| bin1
| 6.2e-06
|
| +4
|
| -14
|
| +2
|
| -3
|
| -2
|
| +15
|
| +14
|
| -2
|
| +10
|
| +11
|
| +11
|
| +2
|
|
|
|
|
| mhc_b
| 1.7e-05
|
|
|
| ant1
| 2.1e-05
|
|
|
| enolase_b
| 4.2e-05
|
|
|
| cytochrome
| 4.6e-05
|
| -4
|
| -7
|
| -7
|
| -11
|
| +1
|
| +1
|
| +13
|
| -15
|
|
|
|
|
| mlc-2
| 5.4e-05
|
|
|
| myogenin
| 7e-05
|
|
|
| Na-K
| 8.9e-05
|
| +8
|
| +10
|
| -2
|
| -8
|
| +2
|
| +2
|
| +2
|
| -1
|
| -5
|
|
|
|
|
| Desmin_enhancer,
| 0.00012
|
|
|
| aB
| 0.00014
|
| +2
|
| +2
|
| +14
|
| -12
|
| +2
|
| +7
|
| -3
|
| +6
|
|
|
|
|
| myo-D
| 0.00044
|
|
|
| McK_pro
| 0.00049
|
| +10
|
| +2
|
| +14
|
| +14
|
| +10
|
| +14
|
| +8
|
| +2
|
| -10
|
| -8
|
| -7
|
| -10
|
| +2
|
| +14
|
|
|
|
|
| aMPD3
| 0.00086
|
|
|
| tnI_prom
| 0.00099
|
|
|
| tnI_up
| 0.0011
|
|
|
| AchR_gamma
| 0.0014
|
| -13
|
| +7
|
| -14
|
| -14
|
| -13
|
| -7
|
| +7
|
| -14
|
| +2
|
| +10
|
| +10
|
| -2
|
|
|
|
|
| myosin_b
| 0.0014
|
|
|
| tnc
| 0.0022
|
|
|
| sm22-alpha
| 0.0036
|
|
|
| acetylcholinesterase
| 0.0046
|
|
|
| myoglobin
| 0.0047
|
|
|
| ryanodine
| 0.0057
|
|
|
| aldolase-a
| 0.0064
|
|
|
| atrial
| 0.015
|
|
|
| tnI_frst_int
| 0.019
|
|
|
| PgaM-M
| 0.037
|
|
|
| ventrical/slow
| 0.043
|
|
|
| McK_enh
| 0.049
|
|
|
| AchR_epsilon
| 0.1
|
|
|
| AchR_delta,
| 0.11
|
|
|
| dystrophin_intron
| 0.2
|
|
|
| Desmin_promoter
| 0.28
|
|
|
| dystrophin_promoter
| 0.35
|
|
|
| retinoblastoma
| 0.37
|
|
|
| skeletal
| 0.42
|
|
|
| MLc1/3
| 0.58
|
|
|
| glut4
| 1.2
|
|
|
| AChR_beta
| 1.4
|
|
| SCALE
|
| | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| 1 |
25 |
50 |
75 |
100 |
125 |
150 |
175 |
200 |
225 |
250 |
275 |
300 |
325 |
350 |
375 |
400 |
425 |
450 |
475 |
500 |
525 |
550 |
575 |
600 |
625 |
650 |
675 |
700 |
725 |
750 |
775 |
800 |
825 |
850 |
875 |
900 |
925 |
950 |
975 |
1000 |
1025 |
1050 |
1075 |
1100 |
|
|---|
SECTION III: ANNOTATED SEQUENCES
- The positions and p-values of the non-overlapping motif occurrences
are shown above the actual sequence for each of the high-scoring
sequences from Section I.
- A motif occurrence is defined as a position in the sequence whose
match to the motif has POSITION p-value less than 0.0001 as
defined in Section II.
- For each sequence, the first line specifies the name of the sequence.
- The second (and possibly more) lines give a description of the
sequence.
- Following the description line(s) is a line giving the length,
combined p-value, and E-value of the sequence as defined in Section I.
- The next line reproduces the motif diagram from Section II.
- The entire sequence is printed on the following lines.
- Motif occurrences are indicated directly above their positions in the
sequence on lines showing
- the motif number of the occurrence (a minus sign indicates that
the occurrence is on the reverse complement strand),
- the position p-value of the occurrence,
- the best possible match to the motif (or its reverse complement), and
- columns whose match to the motif has a positive score (indicated
by a plus sign).
neurofilament
light chain s70309 (1150-2178) chr8:29424848-29425891
LENGTH = 1029 COMBINED P-VALUE = 6.90e-14 E-VALUE = 3.2e-12
DIAGRAM: 42-[-7]-3-[-11]-78-[-6]-136-[+6]-1-[+6]-48-[+3]-[+4]-7-[+3]-13- [+7]-50-[-4]-47-[+3]-27-[-10]-19-[+7]-73-[-14]-20-[+3]-17-[-12]- 96-[-8]-104-[+14]-3-[-13]-2-[-13]-24
[-7] [-11]
4.8e-05 4.6e-05
CCAGCTTTCTG AGCCAGGGAGC
+++++ +++ + +++++ +++
1 CGGACTTTAAATGTGCTGCGGTTGGTGGTAGCAAGCAGGAATTTAGCTTGGTGAGGATCCAGGCAGCTTGAAGCT
[-6]
5.8e-
ACATA
++ ++
76 CCCGGCTGCGGACGCGCGGCTCCCTCAGCAAGTCAGTCTCTGTGTTTCCAACTCTTTCTCTGCCCTCACCACCCA
06
CACACT
++++++
151 CACACTGCAACACGTTAAAGCCATCTGCGGCTTCATTCTCAGTTAAGAAATGTGAAAATCTAGAAACACTAACAG
[+6]
5.3e-07
AGTGTGTA
++++++++
226 GCGGATTAACTGCTGTAATGGTTTAAAAATGCTAAACCAATACCTGCAGTAGTGCCGCAGTTTCACGAGTGTGTG
[+6] [+3]
1.3e-06 1.0e-06
TGT AGTGTGTATGT AAAAAAAAGGAA
+++ +++++++++++ ++++++++++++
301 TGTGTGTGTGTGTGTGCGCGCGCGCGCATCGCGCGACATTCCCTATGTGTTAAGCAGCTCATTAAAGAAAAAGAA
[+4] [+3] [+7]
3.5e-05 1.5e-05 1.2e-06
AAATAAAT AAAAAAAAGGAA CAGAAAGCTGG
++++++++ ++++++ +++++ +++++++++ +
376 AAATAAATCAGGAGAAAGGAAGATGAATTGCAGAAAGTGCCAGAAAGCTAGAAAGAAATTAAAATCTTCTCCATA
[-4]
3.5e-05
ATTTATTT
++++++++
451 CATCATGCATACACATAACCTAGCCTATTTATTTGTATCTAAAATTCCCTAGCCGCACCATCACCGTAAACACCA
[+3] [-10]
4.8e-05 3.5e-07
AAAAAAAAGGAA GGGCACTGAGTG
+++++ ++++++ ++++++++++++
526 AGGGAAAAAATTAAGGAGGTTCCTGGTGGGAAAAGGGCGAGTTGGGGGGACAGGGTGTCTGCGAGGTGACGGGAT
[+7]
1.1e-05
CAGAAAGCTGG
++++++ ++ +
601 ACAGAAAACTAGGGTGTCAAAAGGGAGCAACAACCTGTTTTGGGGGCAACTTAAGGATCCAAGTGTCACGGGGTC
[-14] [+3] [-12]
2.6e-05 1.5e-05 1.6e-
AGGATGGGAGG AAAAAAAAGGAA TCAGA
++++ ++++++ ++++++++++++ +++++
676 TGGGCAATGCAGGACGGGAGGGGCTGCGTGAGTGAGTACAGAAGGGAAATGAGTGAGGGGGCATGGGATCTCAGA
05
GAA
+++
751 GAAAATCAGGGCCCTCTGAGCAAAGTGGAAAGGACGACCGCCGCAGCTCCTCGGGCCGTAGCTCGACCCCGCCTT
[-8]
7.1e-07
TGGCTCAAGGAG
++++++++++++
826 CCCTTTTGCGCAGAATCCTCGCCTTGGCTGCAGCAGCGCGCTGCCCCCACTGGCCGGCGTGCCGTGATCGATCGC
[+14]
1.3e-06
CCTCCCATCC
++++++++++
901 AGGCTGCGTCAGGAGCCTCCCGGCGTATAAATAGGGGTGGCAGAACGGCGCCGAGCCGCACACAGCCATCCATCC
[-13] [-13]
6.9e-07 6.0e-06
T CCTCCCATCTCT CCTCCCATCTCT
+ ++++++++++++ +++ ++++++++
976 TCCCCCTTCCCTCTCTCCCCTGTCCTCTCTCTCCGGGCTCCCACGCCGCCGCGG
Actin,
alpha cardiac promoter -485 to +68 m13483 chr15:31060506-31061057
LENGTH = 553 COMBINED P-VALUE = 4.86e-12 E-VALUE = 2.2e-10
DIAGRAM: 17-[-5]-16-[-7]-60-[-14]-26-[-11]-16-[+2]-20-[-2]-21-[-2]-23-[-2]- 18-[+11]-7-[-2]-73-[-2]-51-[+8]-2-[+10]-61
[-5] [-7]
1.6e-05 1.0e-05
CTGTTGCT CCAGCTTTCTG
++++++++ +++++++++ +
1 TGGAAGATGAGAAGCCGCTGTTGCTCCCCTGCCGCCCTGGCCCAGCTGTCAGGACCCCTCAGCAGAGGGCAGGGC
[-14] [
1.9e-06 1
AGGATGGGAGG A
+++++++ +++ +
76 GCCAAGCCTTCCCACTGCATGTGGCTTATTGTCCCCAAGGCTGGCAGGGCTGCGGAGGACCGAATCCACAGACCA
-11] [+2] [-2]
.1e-06 7.1e-06 1.0e-05
GCCAGGGAGC AGGGGAGGGGG CCCCCTCCCCT
+++++++++ ++++++++++ +++++ ++++
151 TCCAGGGAGCACCCACACCCCAGAAAGGGGGAGGGGTGGGCTGGCGTCACTTAGTCTTCCCCTGCCCCCTACCCT
[-2] [-2]
3.2e-05 1.4e-07
CCCCCTCCCCT CCCCCTCCCCT
+++++ ++++ +++++++++++
226 TCAGCGCCTGCCCCTCCCCAGCTCCCTATTTGGCCATCCCCCTGACTGCCCCCTCCCCTTCCTTACATGGTCTGG
[+11] [-2]
1.2e-07 8.2e-06
GCTCCCTGGCT CCCCCTCCCCT
+++++++++++ +++++ ++++
301 GGGCTCCCTGGCTGATCCTCTCCCCTGCCCTTGGCTCCATGAATGGCCTCGGCAGTCCTAGCGGGTGCGAAGGGG
[-2]
3.7e-07
CCCCCTCCCCT
+++++++++++
376 ACCAAATAAGGCAAGGTGGCAGACCGGGCCCCCCACCCCTGCCCCCGGCTGCTCCAACTGACCCTGTCCATCAGC
[+8] [+10]
1.2e-07 3.5e-07
CTCCTTGAGCCA CACTCAGTGCCC
++++++++++++ ++++++++++++
451 GTTCTATAAAGCGGCCCTCCTGGAGCCAGCCACCCAGAGCCCGCTGCCGCCGGAGCCGAGCCGACCCGCCCCGCC
MLc1A
aka MLc1emb x58851 chr17:51648318-51648969
LENGTH = 650 COMBINED P-VALUE = 1.74e-09 E-VALUE = 8e-08
DIAGRAM: 40-[+15]-34-[+13]-30-[-5]-5-[+11]-28-[-10]-65-[+1]-2-[-2]-40-[+11]- 107-[+2]-78-[-5]-8-[-2]-26-[+2]-9-[-13]-41
[+15]
1.1e-05
TTCCTGGG
++++++++
1 TGTGTAAGGGGGTAGATCTAGGGATCTGAGGTCTGTGGAGTTCCTGGGATGCCTGCTCTGGAAAATGGAGGCTTT
[+13] [-5] [+11]
2.5e-06 1.6e-05 8.9e-06
AGAGATGGGAGG CTGTTGCT GCTCCCTGGCT
++++++++++++ ++++++++ +++++ ++ ++
76 CATCCTGTGAGTTGGGAGGGTGTGGGGCAGTGTGGGTTGGCTGGACCAGCTGTTGCTTCAGAGCTCCATGCCTGG
[-10]
5.1e-07
GGGCACTGAGTG
++++ +++++++
151 AGAGTTGGGCCTCTAGGCAGAGCTGAGGGCCCAGAGTGGCTCTCAGCTTAAAGGATCTTGGCTTAGAAGGAATGT
[+1] [-2]
2.7e-06 5.9e-06
CTAAAAATAGC CCCCCTCCCCT
+++++++++++ + +++++++++
226 GCAGTGGGCTGCCTCTGCTCGGGAGGGGCTAAAAAAAGCCTCACCCTCCCCTGGGCTTTGTGTGAGGCTTATCAA
[+11]
3.7e-05
GCTCCCTGGCT
+++ ++++++
301 CTGCTCAAGTCAGCTCATCTCTCTGGCTGCTCCGGCATATTTGAGAAGGTCTGTTTCCCTGGTCCTTCTGGGTTT
[+2]
1.4e-07
AGGGGAGGGGG
+++++++++++
376 CCACCAATTGGCAAGAAGGGATCAGCCTGTCCTAGAGGTGAAGAGAGAGCTGTGGCATGAAGGGGAGGGGGCTGG
[
3
C
+
451 TGGCCCCAAACCTGGTGACAATACACAGTTGTCAGCTGTACCCTGCTGGCGTTTCTTCCTTTTATAGTCAGCAGC
-5] [-2] [+2] [-1
.1e-05 3.7e-05 2.4e-05 9.5
TGTTGCT CCCCCTCCCCT AGGGGAGGGGG CCT
+++++++ + ++++ ++++ ++++ ++++ + ++
526 AGTTGCTCTTGCTTTCACCCAGCCCCTCTGTGGGGCTCCTGCCCAGGATAAAAGGGAAGGGAGGCAGCCCAGGCT
3]
e-06
CCCATCTCT
+++++++++
601 CCTATCTCATCTCCCAGACGCCACGTCTCTCGGTTTCTTCTTAGATCACT
sarcomeric
mitochondrial creatine kinase -921...+6 m72981 (1360...2285) chr5:88676418-88677359
LENGTH = 926 COMBINED P-VALUE = 1.23e-08 E-VALUE = 5.6e-07
DIAGRAM: 124-[+3]-2-[-1]-34-[-12]-30-[+15]-[-2]-11-[+12]-143-[-1]-35-[-1]- 86-[+7]-35-[-14]-5-[-2]-18-[+8]-2-[+8]-68-[+13]-41-[+14]-72-[-12]-52
[+3] [-1]
6.9e-05 9.3e-05
AAAAAAAAGGAA GCTATTTTTAG
+++++++++ ++ + +++++++++
76 TCCCGCCAAAAGGCCCCCTCACGTGCTCTCCCTGTCAGTACCCCATGCAAAGGTAAAATAGATGATATTTTTAAA
[-12] [+15
1.6e-05 1.1e
TCAGAGAA TTCC
++++++++ ++++
151 CATGGGTCGTGTTTAAAAGAAATGGAAACTCCTTCAGAGAATGAAGGAGAACCACACTGGGTAGAAGGTTATTCC
] [-2] [+12]
-05 4.7e-05 2.9e-05
TGGGCCCCCTCCCCT TTCTCTGA
++++ + ++++++++ ++++++++
226 TGGGGCTCCACCCCTTACTCCTACAGTCCTCTGAGCATGAGTCGGGTCTCGAGAAGGAAGAGACAGGAACCAATT
[-1] [-
7.1e-05 2.
GCTATTTTTAG GC
++++++++ ++ ++
376 TGCTGTCCAAAATCCTGCTGGGTCATTGCTATTTACAGGCAGCCTTCCCGCGTGCGGTGATATCCCAAGCGGGGC
1]
3e-06
TATTTTTAG
+++++++++
451 TATTTTTAAGCAGGGCTATGGCCTGCCGTGGGTTAAGCTGGTGTGGACAGAAGCGAGATGATCTAGCCATCTACT
[+7] [-14]
7.3e-06 2.5e-05
CAGAAAGCTGG AGGATGGGA
++++++ +++ + +++++++
526 GCAGGGGGCCTGATCTTGAACAGAAACCTGACTGTAATTGTCCCTGGATCCAGGTCCCAGACAAAGACGCTGGAA
[-2] [+8] [+8]
1.3e-05 4.1e-07 2.7e-06
GG CCCCCTCCCCT CTCCTTGAGCCA CTCCTTGAGCCA
++ ++ +++ ++++ ++++++++++++ +++++++++ ++
601 GGAGGTCCCTCCAGCCCCTCCTCAGGGCCCGGTCAGCTGCTGGAGCCAGGCAGCTTGAGACATCCTCCTCTCCGA
[+13]
7.4e-06
AGAGATGGGAGG
++++++++++++
676 CCTTGGCTTGAGGGGTTCATCCTCCAAGCTCACCAGGGCCCCAAGCTGGTACACCTGAGAGAAGAGAGAAACAAA
[+14]
2.2e-05
CCTCCCATCCT
++++++++ ++
751 TCCCCCAACAGATGTGCAATTTCACCTGCTGGCCCTTCCATTCTGAGATCCAGAGCCCTGGCAAAGGAGCCTCCA
[-12]
1.6e-05
TCAGAGAA
++++++++
826 GGACCAGGCCTGGGAAGCAAGACTGGCTCCGCTTTTACGTTTCAGAGAAAGGGCAGTGCTATAAAGGGCCCAGCG
MLc1/3_3f
promoter (-550 to +15) chr2:220267506-220268074
LENGTH = 566 COMBINED P-VALUE = 1.40e-08 E-VALUE = 6.5e-07
DIAGRAM: 69-[+12]-26-[-12]-236-[-13]-31-[+1]-76-[+7]-2-[-7]-16-[+3]-5-[-11]- 4-[+10]-5
[+12]
2.9e-0
TTCTCT
++++++
1 GAAAGACCTGACCAGATTGTCACTTGGGTGCGCTCTAAGAAACATGCAGAATGTGCATGGCCTTTTCAGTCCTCT
[-12]
5 2.9e-05
GA TCAGAGAA
++ ++++++++
76 GAACTTTACCATAAACGGACAGTACACTTCAGAGGATGCTCCTGCTATAGCAGTTGCCATTTGAAACCCCAAACC
[-13]
6.5e-06
CCTCCCATCTCT
+++++++++++
301 TGCTCCAAGAGAACATCTTGGAAATAAAGACCATAAAAGTACCGGCAGCTTCCATCTCACTATGGCTGTCTACTC
[+1]
4.0e-07
CTAAAAATAGC
+++++++++++
376 CAAGGTTCTGGTCATCTAAAAATAGCTCTCAGGGTACAGATCCATCTTTCCCTTTGCCCTAAGAAAGCTAAAGAA
[+7] [-7] [+3]
5.6e-05 4.4e-05 1.2e-05
CAGAAAGCTGG CCAGCTTTCTG AAAAAAAA
+ ++++ +++ + +++++++ + +++ ++++
451 CTCTCCAAGGGGTGTGGCAACTTATCTCTGAAACCTGATGCTAGCTGTGAGGTCAAAGCTTGCCCAGAAATAAAA
[-11] [+10]
5.2e-07 2.3e-06
GGAA AGCCAGGGAGC CACTCAGTGCCC
++++ +++++++++++ +++++++ + ++
526 GGAAGCCTCAGCCAGGGAGGACCCCACTCAGGGACCGGAGC
cardiac
alpha-MHc x05632/m25162 chr14:20350666-20351052
LENGTH = 386 COMBINED P-VALUE = 3.11e-08 E-VALUE = 1.4e-06
DIAGRAM: 8-[-6]-50-[-14]-25-[-7]-16-[+2]-11-[+1]-6-[-11]-74-[+2]-14-[+2]- 34-[+2]-49
[-6] [-14]
3.8e-05 3.6e-0
ACATACACACT AGGATG
++ + +++ ++ +++ ++
1 AGAAGGTGACCCTCACCCATGTTTTCAGTCTCACTTCGGGGGAAAAATAACTGAGGTAAGGGCCATGGCAGGGTG
[-7] [+2]
6 2.8e-06 7.0e-05
GGAGG CCAGCTTTCTG AGGGGAGGGGG
++++ ++++++ ++++ ++++++++
76 GGAGAGGCGGTGTGAGAAGGTCCTGTCTTCCCAGCTATCTGCTCATCAGCCCTTTGAAGGGGAGGAATGTGCCCA
[+1] [-11]
2.3e-05 1.8e-06
CTAAAAATAGC AGCCAGGGAGC
++++++++++ ++++++ ++++
151 AGGACTAAAAAAAGGCCGTGGAGCCAGAGAGGCTGGGGCAGCAGACCTTTCTTGGGCAAATCAGGGGGCCCTGCT
[+2] [+2]
3.2e-05 8.2e-06
AGGGGAGGGGG AGGGGAGGGGG
+ ++++++ ++ +++++++++ +
226 GTCCTCCTGTCACCTCCAGAGCCAAAGGATCAAAGGAGGAGGAGCCAGGAGGGGAGAGAGGTGGGAGGGAGGGTC
[+2]
1.0e-05
AGGGGAGGGGG
+ +++++++++
301 CTCCGGAAGGACTCCAAATTTAGACAGAGGGTGGGGGAAACGGGATATAAAGGAACTGGAGCTTTGAGGACAGAT
bin1
1275...2162 u83999 (-775...+112) chr2:131654025-131654911
LENGTH = 886 COMBINED P-VALUE = 1.35e-07 E-VALUE = 6.2e-06
DIAGRAM: 149-[+4]-116-[-14]-48-[+2]-61-[-3]-14-[-2]-12-[+15]-129-[+14]-100- [-2]-6-[+10]-5-[+11]-1-[+11]-93-[+2]-24
[
6
A
76 GACCGAATGAAATAATGCCTGTCAAGTCACTTAGTACACAGTAAGCACTCAGTAATGCTAGGTTGTTGTTATTAT
+4]
.9e-05
AATAAAT
+++++++
151 AATAAATTTTTAGCGAACGGGGAAGACCAAGCACCGGTTGGTACTGGGTTAGGCGCCGTAGGGCAAAGATGTGGA
[-14]
2.6e-07
AGGATGGGAGG
+++++++++++
226 GATGTCCCGGAGGCGCCTAGGGTATCCGGGCGAAAACCCGAGGGCCGAAGGCTGGGAGGAGGCGGAGCGTCGGGC
[+2]
4.0e-05
AGGGGAGGGGG
+ ++++++++
301 ACCGGGCACCGGGCGGGAGGTGAGCCCCTGGAAAAGGAGGGGACTCCGGGCGCGTTCTCCCAGCAGCCGCGGCTC
[-3] [-2]
8.9e-05 6.2e-05
TTCCTTTTTTTT CCCCCTCCCCT
+ ++++++++++ ++ +++++++
376 CTCTGTTCAGGGCCGCGCCCCCTTCGCCGCACTTTTTCTTTGATTTCGAAAGCACTCCTCTCCTCCACCTAGTCT
[+15]
1.1e-05
TTCCTGGG
++++++++
451 CCTTTCCTGGGTTGCAGGAGAGTTACTGCTTTGCGGGGAAAGAACAAGACGCCAGGCCGGCGGATTAGTCCCCGC
[+14]
1.3e-06
CCTCCCATCC
++++++++++
526 CCCGGGGCGGTGCAGCTGGAGCGTCAGGGGAGTCCCGCTCGCCGCAGCCCCAGCGCCGCGCGCGCCCATCCATCC
T
+
601 TAGAAGGACCTGGCGGTGCCGGCGCCCGGAGTGGCCCTTTAAAAGGCAGCTTATTGTCCGGAGGGGGCGGGCGGG
[-2] [+10] [+11] [+1
8.9e-06 2.3e-06 4.0e-07 4.0
CCCCCTCCCCT CACTCAGTGCCC GCTCCCTGGCT GCT
++++++++++ + ++++++++++ ++++ ++++++ +++
676 GGGCGCCGACCGCGGCCTGAGGCCCGGCCCCTCCCCTCTCCCTCCCTCTGTCCCCGCGTCGCTCGCTGGCTAGCT
1]
e-07
CCCTGGCT
+ ++++++
751 CGCTGGCTCGCTCGCCCGTCCGGCGCACGCTCCGCCTCCGTCAGTTGGCTCCGCTGTCGGGTTGCGCGGCGTGGA
[+2]
2.8e-06
AGGGGAGGGGG
++++ ++++++
826 GCGGCAGCCGGTCTGGACGCGCGGCCGGGGCTGGGGGCTGGGAGCGCGGCGCGCAAGATCT
mhc_b
upstream enhancer 980...1246 m57965 (-2823...-2554) chr14:20380607-20380877
LENGTH = 268 COMBINED P-VALUE = 3.73e-07 E-VALUE = 1.7e-05
DIAGRAM: 23-[+12]-60-[-10]-49-[-3]-37-[+14]-3-[-1]-13-[-3]-17
[+12]
2.9e-05
TTCTCTGA
++++++++
1 CTGGGAGTAATTTTAGCAACTTTTCCTCTGAACTACCGCTGGCGTGTTCACAGCAAATGGCCCCTGTTTTGGCTT
[-10]
1.4e-06
GGGCACTGAGTG
++ +++++++++
76 GACACTTGATCAGGGTGGTGACAGAGTGCAGACAAAGCCGGCACAATGCGGGGAGGGGAGGACCGGGGCAGATCA
[-3] [+14] [-1]
5.3e-05 5.8e-07 9.6e-06
TTCCTTTTTTTT CCTCCCATCCT GCTATTTTTA
++++++++ +++ +++++++++++ ++++++++++
151 CCTTCCTTTCACTTCAGGGCCTTATTTGGTCTACCTTGCCGAAGCGGCCCTCCTTCCAGCCTCTCTTTATTTATA
[-3]
1.2e-05
G TTCCTTTTTTTT
+ ++++++++++++
226 GCATTTTGCTTGCTCTCCTTTATCTTGCTATCACTTGTAGCAC
ant1
promoter -674...+42 J04982 (825..1540) chr4:202563770-202564488
LENGTH = 716 COMBINED P-VALUE = 4.54e-07 E-VALUE = 2.1e-05
DIAGRAM: 38-[-10]-53-[+3]-61-[+13]-43-[-11]-156-[+1]-15-[-10]-123-[+2]-146
[-10]
3.5e-08
GGGCACTGAGTG
++++++++++++
1 AATTCACCTAGTGGCCCCCTGCACCAGGTCTTTCCTGTGGGCACTGAGTGCAGACACATCAATATGTAATAGCAG
[+3]
8.2e-06
AAAAAAAAGGAA
++++++++++++
76 AATGAATGACTGAACGAACGATTGAATGAAAAGAAATGAGAGGCAGCAGGTTGTCAGATTCTATGAGGCAATCAC
[+13]
6.3e-05
AGAGATGGGAGG
++++++++ +
151 AGCATCAGGTGACCTTAGTATCTATTTGAGAGGACTGCCATTTATTCTCGGGAGCGCACGGCTCTAAAGAGGCCC
[-11]
3.4e-06
AGCCAGGGAGC
++ ++++++++
226 ATATCCAGGCAGTGAGCTCTGGTGGGGGGCGCCTTTAGATGCAAGAAGGAGGAAACAGCTCGAAATCCCTGGGCC
[+1] [-10]
9.3e-05 6.8e-05
CTAAAAATAGC GGGCACTGAGTG
+++++++++ ++ ++++ ++++
376 GCCCCGGCCTAAGGCTGCCTGTGCTATAAATACGCGGCCCACATGCCGCGGTGACACGGTGTTCCCTGGGCTCGG
[+2]
7.8e-07
AGGGGAGGGGG
+++++++++++
526 GAAGCGCCTTCGCCCCCGATGCCCTCTGCAGCTGGGAGGAGGGGGCGCCCCGCACCTGCCCAGCCAATGCGCGGC
enolase_b
intronic enhancer 1371..1504 x56832 (+504...+637) chr17:5423729-5423863
LENGTH = 134 COMBINED P-VALUE = 9.20e-07 E-VALUE = 4.2e-05
DIAGRAM: 7-[-14]-23-[+2]-36-[-1]-35
[-14] [+2]
1.4e-07 2.5e-07
AGGATGGGAGG AGGGGAGGGGG
+++++++++++ +++++++++++
1 GATTCTTAGGATGGGAGGGTGGAATAAGAGCTGTTCTGAGTGGGGGAGGGGGCTGCGCCTGCCTCTTTGGTCTGT
[-1]
1.4e-05
GCTATTTTTAG
+ +++++++++
76 GACCTTTTTGTAGGGTATTTTTAGCTCCAGCACCTGCCTTCTTGGAGTGGGGAAGAATC
cytochrome
oxidase VIa -280...+17 (490-790) u66875 chr16:36051799-36052099
LENGTH = 300 COMBINED P-VALUE = 1.00e-06 E-VALUE = 4.6e-05
DIAGRAM: 5-[-4]-4-[-7]-109-[-7]-12-[-11]-7-[+1]-5-[+1]-34-[+13]-11-[-15]-30
[-4] [-7]
6.9e-05 1.5e-05
ATTTATTT CCAGCTTTCTG
+++++++ +++ +++++++
1 CAAATATTTATTAAAGCCCAACTGTGTGCCAGCCACCAGGCATAGAATAGGGAACAAAATAGTTTCCCTGCAACT
[-7]
5.7e-06
CCAGCTTTCTG
++++++++++
76 ATATAAAAAGAATGGCATATTGTACTTAAATGCCTCCTTGCCAAAATAAGAGGCACAGGACAACAGCTGTCTGGA
[-11] [+1] [+1]
3.7e-05 5.9e-05 4.0e-05
AGCCAGGGAGC CTAAAAATAGC CTAAAAATAGC
+++++++ +++ +++++ +++++ ++++ ++++++
151 GATGACCTCAAGCCAGTCAGGCCCCATTTTAAATATAGAAACCCCTAAGAATAGCCGCCAGTGCTCCAGACTCAA
[+13] [-15]
2.0e-07 1.1e-05
AGAGATGGGAGG CCCAGGAA
++++++++++++ ++++++++
226 CAGGTGATTGGCCCAGAGAGGGGAGGTGACCCCAGGCCCCAGGAAAGGGAGCGAGGACAGCGCTGGTTCCCGGCT
mlc-2
Z15030 (1080-1238) chr12:128315753-128315911
LENGTH = 158 COMBINED P-VALUE = 1.18e-06 E-VALUE = 5.4e-05
DIAGRAM: 26-[+2]-50-[-1]-3-[+2]-9-[+15]-3-[+7]-15
[+2]
8.2e-06
AGGGGAGGGGG
++++++++++
1 GCCACCCTTACTTCAGAAGAACGGCATGGGGTGGGGGGGCCTTAGGTGGTGCCCGCCTCACCTATGACTGCCAAA
[-1] [+2] [+15] [+7]
6.1e-06 5.7e-05 1.1e-05 4.3e-06
GCTATTTTTAG AGGGGAGGGGG TTCCTGGG CAGAAAGCTGG
+++++++++++ +++++++ + ++++++++ ++++ ++++++
76 AGCGGTCATGGGGTTATTTTTAAACATGGGGAGGAAGTATTTATTGTTCCTGGGCTGCAGAGAGCTGGGCGGAGT
myogenin
(myf4) promoter -211 to +54 chr1:237013719-237014005
LENGTH = 286 COMBINED P-VALUE = 1.53e-06 E-VALUE = 7e-05
DIAGRAM: 9-[+2]-11-[+3]-34-[+5]-12-[-7]-8-[-1]-159
[+2] [+3]
8.2e-06 8.3e-05
AGGGGAGGGGG AAAAAAAAGGAA
++++++++++ ++++++ ++++
1 CTGGCAGGGTGGGGTGGGGGCCATGCGGGAGAAAGAAGGGGAATCACATCTAATCCACTGTAAACGCCTTGATGT
[+5] [-7] [-1]
1.6e-05 7.3e-06 8.4e-05
AGCAACAG CCAGCTTTCTG GCTATTTTTAG
++++++++ +++ ++++++ +++++ ++++
76 GCAGCAACAGCTTAGAGGGGGCTCAGGTTTCTGTGGCGTTGGCTATATTTATCTCTGGTTCCATGCCAGCGGGGA
Na-K
atPase alpha 2 -360...+60 j05096 (1220...1640) chr1:189149551-189149971
LENGTH = 420 COMBINED P-VALUE = 1.94e-06 E-VALUE = 8.9e-05
DIAGRAM: 72-[+8]-22-[+10]-4-[-2]-96-[-8]-4-[+2]-34-[+2]-4-[+2]-9-[-1]-5- [-5]-71
[+8
7.1
CTC
+ +
1 CAGTTTACCCACTTGGAAAAGAAGAGTTAGGCCACATGGTCTCTGTCATCCTGGGATTCTGAGTCAACTGCTCCC
] [+10] [-2]
e-07 9.9e-05 5.1e-06
CTTGAGCCA CACTCAGTGCCC CCCCCTCCCCT
+++++++++ ++ ++++ + ++ ++++++ ++++
76 CTTCAGCCAGATCCTAGGGGGCATATCCCCCCAACCTGGGACCCAGGCCCCCTTCCCTTGCAGCCTCTCTCAGTT
[-8] [+2] [+2]
1.5e-06 2.2e-05 5.9e-06
TGGCTCAAGGAG AGGGGAGGGGG AGGGGAGGGG
+++++ ++++ + ++++++++ + ++++++++++
226 CCAGTGGCTAAAGGGGCGGGAGGGGAGGAGTCCTCAGGGATCCTGTTTCAACAAACGTTTCTTTCGGAGGAGGGG
[+2] [-1] [-5]
8.2e-06 4.9e-05 1.6e-05
G AGGGGAGGGGG GCTATTTTTAG CTGTTGCT
+++++++ +++ ++++++++++ ++++++++
301 AAGGCGGGGGAGAGGGGGAGAAGGACCTATTTAAAGCTACCCTGTTGCTTTGGCTTTCTCTGTCTGCCAGGGTCT
Desmin_enhancer,
-973 to -848 m63391 chr2:229782794-229782921
LENGTH = 126 COMBINED P-VALUE = 2.69e-06 E-VALUE = 0.00012
DIAGRAM: [-2]-45-[+1]-24-[-5]-27
[-2] [+1]
1.3e-06 2.1e-05
CCCCCTCCCCT CTAAAAATAGC
++++++ ++++ +++++++++ +
1 CCCCCTGCCCCCACAGCTCCTCTCCTGTGCCTTGTTTCCCAGCCATGCGTTCTCCTCTATAAATACCCGCTCTGG
[-5]
1.6e-05
CTGTTGCT
++++++++
76 TATTTGGGGTTGGCAGCTGTTGCTGCCAGGGAGATGGTTGGGTTGACATGC
aB
crystallin -661...+10 M28638 (270..940) chr11:127407843-127408513
LENGTH = 670 COMBINED P-VALUE = 3.14e-06 E-VALUE = 0.00014
DIAGRAM: 113-[+2]-210-[+2]-14-[+14]-47-[-12]-1-[+2]-20-[+7]-48-[-3]-12-[+6]- 119
[+2]
1.3e-05
AGGGGAGGGGG
++++++++++
76 GAACGAAAGATGCAAGAAATCTGTTTGCTCTTTTTTCAGGGGGTGGGGTCTTTCTGCCCAGATGTGGGATCCTCT
[+2] [+14]
4.3e-06 1.3e-05
AGGGGAGGGGG CCTCCCATCCT
++++++++ ++ ++++++++++
301 CTGGCCTGATTCCCCTGGCATTCAGGACTGGAAAGGAGGAGGAGGGGCACACTACGCCGGCTCCCATCCTCCCCC
[-12] [+2]
1.6e-05 3.7e-07
TCAGAGAA AGGGGAGGGGG
++++++++ +++++++++++
376 CACCCCGCGTGCCTGCTTGGGATTCCTGACTCTGTACCAGCTTCAGAGAACAGGGGTGGGGGTGGGTGCCATTGG
[+7] [-3]
1.2e-06 8.9e-05
CAGAAAGCTGG TTCCTTTTT
+++++++++ + ++++ ++++
451 GTGTGGACAGAAAGCTAGTGAAACAAGACCATGACAAGTCACTGGCCGGCTCAGACGTGTTTGTGTCTCTCTTTT
[+6]
6.7e-05
TTT AGTGTGTATGT
+++ + +++++++++
526 CTTAGCTCAGTGAGTACTGGGTATGTGTCACATTGCCAAATCCCGGATCACAAGTCTCCATGAACTGCTGGTGAG
myo-D
distal enhancer approx -20k typed in chr11:18004960-18005218
LENGTH = 258 COMBINED P-VALUE = 9.60e-06 E-VALUE = 0.00044
DIAGRAM: 64-[+8]-23-[+7]-54-[+2]-83
[+8]
3.7e-05
CTCCTTGAGCC
++ +++++++
1 CCACAGCAGTTGGGGGCATTTATGGGCCTTCCTATAAACTTCTGAGAGGGTAACTTTATCCTGCTTCTTTCAGCC
[+7]
6.2e-07
A CAGAAAGCTGG
+ +++++++++++
76 AAGTATCCTCCTCCAGCAGCTGGTCACAAAGCTGGTTAATCTCCCAGAGTGCTCAGCTTAAAACCCGTGACTCAC
[+2]
2.5e-07
AGGGGAGGGGG
+++++++++++
151 AGCACAGCCAGTGTGGGGGAGGGGGTGGCTGCCTCCAATACGTGGCGCCCAGAGTCAGCTGTTCTGGGGCCTTCT
McK_pro
5' promoter m21487chr19:56172776-56173503
LENGTH = 718 COMBINED P-VALUE = 1.07e-05 E-VALUE = 0.00049
DIAGRAM: 3-[+10]-47-[+2]-7-[+14]-25-[+14]-12-[+10]-62-[+14]-31-[+8]-36-[+2]- 6-[-10]-25-[-8]-120-[-7]-68-[-10]-11-[+2]-45-[+14]-60
[+10] [+2]
3.9e-06 7.1e-06
CACTCAGTGCCC AGGGGAGGGGG
+ ++++++++++ +++++++++ +
1 ACCCTCCCTGTCCCCGCACAGCGAAATCTCCCAGTGGCACCGAGGGGGCGAGGGTTAAGTGGGGGGGAGGGTGAC
[+14] [+14] [+10]
7.0e-07 8.5e-06 1.2e-06
CCTCCCATCCT CCTCCCATCCT CACTCAGTGCC
+++++++ +++ ++ +++++++ +++++++++++
76 CACCGCCTCCCACCCTTGCCCTGAGTTTGAATCTCTCCAACTCAGCCAGCCTCAGTTTCCCCTCCACTCAGTCCC
[+14]
8.0e-05
C CCTCCCATCCT
+++++ ++++
151 TAGGAGGAAGGGGCGCCCAAGCGGGTTTCTGGGGTTAGACTGCCCTCCATTGCAATTGGTCCTTCTCCCGGCCTC
[+8]
1.2e-07
CTCCTTGAGCCA
++++++++++++
226 TGCTTCCTCCAGCTCACAGGGTATCTGCTCCTCCTGGAGCCACACCTTGGTTCCCCGAGGTGCCGCTGGGACTCG
[+2] [-10] [-8]
1.2e-05 9.0e-05 8.3e-08
AGGGGAGGGGG GGGCACTGAGTG TGGCTCAAGGAG
+++++++ +++ ++ +++++++ + ++++++++++++
301 GGTAGGGGTGAGGGCCCAGGGGCGACAGGGGGAGCCGAGGGCCACAGGAAGGGCTGGTGGCTGAAGGAGACTCAG
[-7]
2.1e-05
CCAGCTTTCTG
++++++ +++
451 GTCCCCACCGCCAGCCCAACTCAGCACTTGGTTAGGGTATCAGCTTGGTGGGGGCGTGAGCCCAGCCCTGGGGCG
[-10] [+2]
2.7e-06 1.8e-05
GGGCACTGAGTG AGGGGAGGG
+++ ++++++++ ++++ ++++
526 CTCAGCCCATACAAGGCCATGGGGCTGGGCGCAAAGCATGCCTGGGTTCAGGGTGGGTATGGTGCCGGAGCAGGG
[+14]
3.0e-06
GG CCTCCCATCCT
+ ++++++++++
601 AGGTGAGAGGCTCAGCTGCCCTCCAGAACTCCTCCCTGGGGACAACCCCTCCCAGCCAATAGCACAGCCTAGGTC
aMPD3
promoter 1b -14...+310 U29927 chr11:10311873-10312200
LENGTH = 327 COMBINED P-VALUE = 1.87e-05 E-VALUE = 0.00086
DIAGRAM: 31-[+15]-82-[-10]-2-[+6]-6-[-13]-145-[+2]-7
[+15]
1.1e-05
TTCCTGGG
++++++++
1 GCTAGCCTCCCGGTAAACAACTGACCCATCCTTCCTGGGCTCTTCTCCCCAGGATTTCAACAGCACCACAGAAAT
[-10] [+6]
1.1e-05 8.2e-06
GGGCACTGAGTG AGTGTGTATGT
+ +++++++ + + +++++ +++
76 AGCCATTTTGCTCATGGTTATTTCCCAGGACCACACGATTTGCCTAAGTCACTGGGAGGCTATGTGTCTGTTCTG
[-13]
5.5e-06
CCTCCCATCTCT
++++++++++++
151 AGCCTTCCCACTCTCCTAAAGGGCAGATGAAGATCAGAGCTTTGCACCCTGTGATGCCATTTTAATCAACCCTGC
[+2]
2.6e-05
AGGGGAGGGGG
++++ +++ ++
301 CCAGCGCTCGGAGCTGGAGGCCCACGT
tnI_prom
slow promoter, -95 to +12 chr1:234828198-234828305
LENGTH = 107 COMBINED P-VALUE = 2.15e-05 E-VALUE = 0.00099
DIAGRAM: 19-[+6]-[-1]-4-[-5]-54
[+6] [-1] [-5]
3.2e-06 6.5e-05 3.1e-05
AGTGTGTATGTGCTATTTTTAG CTGTTGCT
+++++++ +++++++++++++ ++++++++
1 AGGGGCAGCAGGAGGGGGCAGTGGGTCTGTTCTATTTTTACCAGCCAGTTGCTGCTGGACACAGTTTTCATAGCC
tnI_up
slow upstream enhancer, -1041 to -871 chr1:234827260-234827430
LENGTH = 171 COMBINED P-VALUE = 2.42e-05 E-VALUE = 0.0011
DIAGRAM: 3-[+10]-30-[+13]-38-[+12]-34-[+1]-23
[+10] [+13]
9.5e-06 9.5e-06
CACTCAGTGCCC AGAGATGGGAGG
+ +++++ +++ ++++++++ +++
1 CCTCTCTCTGGGCCTCTGAGAGGGTCAGTGTCCTGCCCCAACCCATGAGATGACAGACTATAATAGCCACAGGAT
[+12] [+1]
1.6e-05 1.4e-05
TTCTCTGA CTAAAAATAGC
++++++++ +++++++++ +
76 TAACATAGCAGGCATTGTCTTTCTCTGACTATAGGGTGGGTATTATGTGTTCATCAACCATCCTAAAAATACCCG
AchR_gamma
-404...-33 Z79612 chr2:243774211-243774600
LENGTH = 389 COMBINED P-VALUE = 3.00e-05 E-VALUE = 0.0014
DIAGRAM: 9-[-13]-42-[+7]-39-[-14]-15-[-14]-33-[-13]-18-[-7]-31-[+7]-12-[-14]- 15-[+2]-17-[+10]-2-[+10]-17-[-2]-3
[-13] [+7]
3.1e-05 1.5e-05
CCTCCCATCTCT CAGAAAGCTGG
++ ++++++++ +++ +++++++
1 CAGTCCACCTCAGCCCTCTCTGGAGCCGCTGTCAGGTTCCTCGGCGACCTGCCTTCCCTACCACACCCAGCTGGC
[-14] [-14]
6.3e-05 2.7e-05
AGGATGGGAGG AGGATGGGAGG
+++++++++ ++++++++++
76 CCTGGCTGTCCTTGCCCCCCATGTGGAACATGGAGGTGAGGCTGGGACAACTGAGCCCGAGTTGGGGCTGGAAGG
[-13] [-7]
8.9e-05 1.3e-05
CCTCCCATCTCT CCAGCTTTCTG
+++++++++++ +++++ +++++
151 TGGATGTCTCTTTTGGGGCAGACGGGGCCCCTGTCTCCCCTCTCCAGCCCAGGTAACCTGAGCCCAGCATTGTGT
[+7] [-14]
4.0e-07 6.3e-05
CAGAAAGCTGG AGGATGGGAGG
+++++++++++ +++++++ ++
226 CCATCCTGGAACAGCTGACAACGCTGTGGTCAGACAGCTGGTGGGGCTGGGCCAGGCTGGCCGGGCTGGCTGGGC
[+2] [+10] [+10]
3.2e-05 3.5e-07 6.3e-05
AGGGGAGGGGG CACTCAGTGCCC CACTCAGTGCCC
++++++++ + ++++++++++++ + ++++ +++++
301 TGGCTGGGGTGGGAGTGTAGGCTGTTATATGACACCCAGAGCCCATCTCTCTCTGCCCCAGACCTTGGAGCTGTT
[-2]
5.3e-05
CCCCCTCCCCT
+++++++++
376 GTCCCACCCCTGTC
myosin_b
heavy chain chr14:20378266-20378367
LENGTH = 101 COMBINED P-VALUE = 3.03e-05 E-VALUE = 0.0014
DIAGRAM: 54-[+8]-5-[+10]-18
[+8] [+10
1.6e-06 2.0e
CTCCTTGAGCCA CACT
+++ ++++++++ + ++
1 CCCTCTCCTGCCAGCTGTGGAATGTGAGGCCTGGCCTGGGAGATATTTTTGCTGCACTTTGAGCCACCCCGCCCC
]
-05
CAGTGCCC
+++ +
76 CTGGAACTCAGACCCTGCACAGTCCA
tnc
slow/cardiac first intron enhancer m37984 chr3:59863259-59863576
LENGTH = 310 COMBINED P-VALUE = 4.69e-05 E-VALUE = 0.0022
DIAGRAM: 73-[+10]-54-[-11]-11-[+11]-44-[+1]-83
[+
9.
CA
++
1 TGCTATAGCCAGCTCTGGGGGCACGCCTGCTTATCCTGTGGGAGTCCATGGAGCCGGGGTGGGGACAGCCCTCCA
10] [-11]
8e-08 1.8e-06
CTCAGTGCCC AGCCAGGGAGC
++++++++++ ++++++++ ++
76 CCCAGTGCCCATACAAGGCCTGGCGGAGTTGGGGACTAATTTTGGCTTCTGAGGCGGCACTAGCAGCCAGGGGGC
[+11] [+1]
1.3e-05 2.3e-06
GCTCCCTGGCT CTAAAAATA
++ +++++ + +++++++++
151 CAGATAACGCTGCCCCCTGCATGCCAAAGTCCCCAGAACAATCACCAGGTTTCACTTTGTTCCTCGTTAAAAATA
GC
++
226 GCCCAGTGGCCACCCTGGTCAGGTTACCGTGGGTGGCTTGCCTGCCTCCACACTGGTTTTATTATCCCAACTTAG
sm22-alpha
-140...+1 u73638 (26771..26582 reversed) chr5:24418507-24418697 chr11:133537092-133537282
LENGTH = 190 COMBINED P-VALUE = 7.81e-05 E-VALUE = 0.0036
DIAGRAM: 16-[-7]-28-[-10]-4-[+2]-41-[-11]-38-[+14]-7
[-7] [-10] [+2]
5.0e-05 1.0e-05 4.7e
CCAGCTTTCTG GGGCACTGAGTG AGGG
+++ +++ +++ + +++++++ + ++++
1 GCCCCGGTAGACTGCTCCAACTTGGTGTCTTTCCCCAAATATGGAGCCTGTGTGGAGTCACTGGGGGAGCCGGGG
[-11]
-06 3.8e-06
GAGGGGG AGCCAGGGAGC
++++++ ++++++++ ++
76 GTGGGGAGCGGAGCCGGCTTCCTCTAGCAGGGAGGGGGCCGAGGAGCGAGCCAGTGGGGGAGGCTGACATCACCA
[+14]
9.4e-06
CCTCCCATCCT
+++++++++
151 CGGCGGCAGCCCTTTAAACCCCTCACCCAGCCAGCGCCCC
acetylcholinesterase
gene (approx -180 to +60) U32675 chr7:125980045-125980287 chr7:105667154-105667396
LENGTH = 240 COMBINED P-VALUE = 1.00e-04 E-VALUE = 0.0046
DIAGRAM: 35-[+2]-[+13]-21-[+2]-3-[-11]-30-[+6]-61-[-2]-23
[+2] [+13]
2.0e-05 2.0e-07
AGGGGAGGGGGAGAGATGGGAGG
+ +++++++ +++++++++++++
1 GCGTCTGGGCCCCGGGGTCTCCGGGTCTCGGCTCCAAGGGAGGGAGAGAGAGGGGAGGTGGCCACCCGGGAGAGC
[+2] [-11] [+6]
1.8e-05 7.0e-05 1.1e-05
AGGGGAGGGGG AGCCAGGGAGC AGTGTGTATGT
+++++ +++++ ++ +++++ ++ ++ ++++++++
76 GGGGAGGGGCGGGGGCGGAGACAGTGGGCGGGGGCGGGCGGGGGCGCTGTGAGGCCCGGAGGGGGTGTGTGCGGG
[-2]
2.6e-05
CCCCCTCCCCT
++ +++ ++++
151 GGCCGGAGGCGGCGGCTGTCAGAGTCGGCTCAGCCTGCGCCGGGGAACATCGGCCGCCTCCAGCTCCCGGCGCGG
myoglobin
-373...+7 m10090 (1520...1895) chr22:32656679-32657052
LENGTH = 373 COMBINED P-VALUE = 1.01e-04 E-VALUE = 0.0047
DIAGRAM: 123-[-2]-19-[-2]-71-[+3]-5-[+11]-9-[+3]-3-[+2]-6-[-11]-58
[-2]
1.2e-06
CCCCCTCCCCT
++ ++++++++
76 TTCTGTGGTGCCCTTTCTGTCGGCTATGAGAGTCCAGACAGTGCCCAACCTCCTCCCCTTCTTTCCACACGCACA
[-2]
1.3e-05
CCCCCTCCCCT
++++++++++
151 ACCACCCCACCCCCTGTGGCCTGAGCTGTCCTGCCTCGCCACAATGGCACCTGCCCTAAAATAGCTTCCCATGTG
[+3] [+11] [+3] [+2]
5.8e-05 1.8e-06 6.9e-05 1.4e-07
AAAAAAAAGGAA GCTCCCTGGCT AAAAAAAAGGAA AGGGGAGGGGG
+++++++++++ +++++++++ + +++++ ++++++ +++++++++++
226 AGGGCTAGAGAAAGGAAAAGATTAGACCCTCCCTGGATGAGAGAGAGAAAGTGAAGGAGGGCAGGGGAGGGGGAC
[-11]
2.5e-06
AGCCAGGGAGC
+++++ +++++
301 AGCGAGCCATTGAGCGATCTTTGTCAAGCATCCCAGAAGGTATAAAAACGCCCTTGGGACCAGGCAGCCTCAA
ryanodine
receptor u48449 (1811..2345) chr19:47384984-47385520
LENGTH = 537 COMBINED P-VALUE = 1.24e-04 E-VALUE = 0.0057
DIAGRAM: 129-[-1]-57-[+10]-14-[+13]-65-[-2]-112-[-13]-53-[-8]-17-[-2]-9
[-1]
2.6e-05
GCTATTTTTAG
+++++++++++
76 GGGGTGAGCCACCACTCCCGGCCGGAGTCCTTGTTCTTAATCACTATGTTTGGTGCTTTTTAAAGTCAGGAGATC
[+10] [+
1.4e-06 4.
CACTCAGTGCCC AG
+++++++++++ ++
151 TGGTGCACATCCCTGCTCTGCTGCGTGATATCTTGCAAGAACTTCCCCACTCAGAGCCTCAGTCTGCCCTCTGTG
13]
6e-06
AGATGGGAGG
+ ++++++++
226 AAATGGGAGAATGATGGCACGTTACTTACCGTGGTGGGGAGAAAGCGCAGGTACCTCCTAGATACTCTCTCTCCC
[-2]
2.6e-05
CCCCCTCCCCT
++++++++++
301 ACCCCACCTCCGGCGGCCAACGGCAAGCAAACCTCCAGCCAAGATTTGGGGTATGTGGGCAGGGCTCCGGCGAAG
[-13]
2.0e-07
CCTCCCATCTCT
++++++++++++
376 GGGAGTGGCCGGGGAGTCCTGGTCCAATGGGGCCCGGGGCGGGGACTTCCTCCCATCTCTGTCCAGCATGCGTGT
[-8] [-2]
6.7e-05 2.3e-06
TGGCTCAAGGAG CCCCCTCC
++ ++++++ + ++++++ +
451 ACTCCTCGCAGTTCCATCTACCTCGCGGGTGCCTCTGGTGTCTCCAGAGGTCTCCGACCCCAGCCCGCCCCCAGC
CCT
+++
526 CCTCCCGCCCAG
aldolase-a
pM x12447 -235...27 (1526...1756) chr16:84047306-84047587
LENGTH = 278 COMBINED P-VALUE = 1.38e-04 E-VALUE = 0.0064
DIAGRAM: 11-[-2]-17-[+6]-18-[+1]-28-[+2]-69-[+11]-80
[-2] [+6] [+1]
6.4e-06 3.5e-06 5.9e-05
CCCCCTCCCCT AGTGTGTATGT CTAAAAA
++++++ ++++ ++++++ ++++ +++++ +
1 CAAGTCTTCCTCCCCCTTCCCCATGCCGGGCCCCACGATAGTGTGAATGTCAGGGGCTTCAGGTTTCCCTAAATA
[+2]
2.0e-05
TAGC AGGGGAGGGGG
+++ ++++ +++++
76 TAGGTCCCTGCCAGAGGATCCGTGGCGGGAAAAGGGCAGGGGTCATTAGAGAAGATCGGGGACACATGTGGGGCT
[+11]
2.6e-05
GCTCCCTGGCT
+++++++ +++
151 GGGCAGGAGCTGCCTTATAACCACCCGGGAACCCCTAGCTCACTCGCTGCTGACCAGGCTCTGCCGGCTCCTTGC
atrial
natriuretic factor -134...+65 k02043 (315..545) chr1:12753964-12754193 chr9:140520600-140520829
LENGTH = 228 COMBINED P-VALUE = 3.25e-04 E-VALUE = 0.015
DIAGRAM: 77-[+13]-24-[+2]-1-[+1]-51-[-11]-30
[+13] [+2] [+1]
1.3e-05 5.9e-06 1.5e-05
AGAGATGGGAGG AGGGGAGGGGG CTAAAAATAGC
+++ ++++++++ ++++ ++++++ +++++++++++
76 ACAGAATGGGGAGGGTTCTGTCTCTCCTGCGTGCTTGGAGAGCTGGGGGGCTATAAAAAGAGGCGGCACTGGGCA
[-11]
5.8e-05
AGCCAGGGAGC
+ ++++ ++++
151 GCTGGGAGACAGGGACAGACGTAGGCCAAGAGAGGGGAACCAGAGAGGAACCAGAGGGGAGAGACAGAGCAGCAA
tnI_frst_int
slow first intron enhancer chr1:234830086-234830282
LENGTH = 197 COMBINED P-VALUE = 4.03e-04 E-VALUE = 0.019
DIAGRAM: 86-[+10]-35-[-2]-13-[-2]-12-[+2]-6
[+10] [-2]
1.4e-06 8.2e-06
CACTCAGTGCCC CCCCCTCCCCT
+ ++++++++++ ++ ++++++++
76 TCCATACCCCTCCCTCTGTGCCCCAGCATGACAGCTGAGACTCTGGGGTCACACTACACCTCCACCTCCTCCACC
[-2] [+2]
2.8e-05 6.4e-06
CCCCCTCCCCT AGGGGAGGGGG
+++++++++ ++++++++ ++
151 CCAGCCTTACCCTCCCCTGGTGGCGGAGGCAGAGGTGGAGGGAGGCC
PgaM-M
m55673 (1640...1825) chr7:47699116-47699306
LENGTH = 190 COMBINED P-VALUE = 8.05e-04 E-VALUE = 0.037
DIAGRAM: 15-[-1]-30-[-2]-56-[+2]-[+2]-45
[-1] [-2]
4.5e-06 2.8e-06
GCTATTTTTAG CCCCCTCCCCT
+++++++++++ ++++++ ++++
1 TGGTGGATGCGTGGGGCTATTTTAAGCACAGCCTCTTGGCCTGCACACTCCCCTGGCCCCCAGCCCCCAGCAGCT
[+2] [+2]
7.0e-05 5.7e-05
AGGGGAGGGGGAGGGGAGGGGG
++++++++ +++++ ++++
76 CAGCTACTGGTCACCTGCCACCGCCTGGAATGCTGATTGGCAGTTGGCTGGGGTGGGTGGGGGCTGGGAAGACAC
ventrical/slow
mlc-1 -312...+10 m76408 (1640...1950) chr3:53684868-53685183
LENGTH = 313 COMBINED P-VALUE = 9.29e-04 E-VALUE = 0.043
DIAGRAM: 18-[+6]-15-[+6]-1-[+6]-31-[-2]-29-[-2]-99-[+2]-54
[+6] [+6] [+6]
2.5e-06 5.3e-07 8.1e-07
AGTGTGTATGT AGTGTGTATGT AGTGTGTATGT
+++++++++++ +++++++++++ +++++++++++
1 GAGAGCAGCAGGGCCCTGTGTGGGTATGTGCGGGTGTGCAGATGAGTGTGTGTGTATGTGTGTATGTGTGTGTTA
[-2] [-2]
2.1e-06 5.3e-05
CCCCCTCCCCT CCCCCTCCCCT
+ +++++++++ +++++++++
76 AGCAGTGGCCTTTGTCCCCCTCTCTCCCTCCCCCTTCCCAACAGGTGATTGGGAGGAATGGAGATCCCTCCTCCA
[+2]
1.5e-05
AGGGGAGGGGG
++++++++++
226 GCCCTGTCCCTATTGTGCACTGCAGGGGTGGGGCTGGGGTCATGAGGTATCCGGGCAGGATAAAGGCCTGGGTGA
McK_enh
5' enhancer m21487chr19:56173503-56173711
LENGTH = 207 COMBINED P-VALUE = 1.07e-03 E-VALUE = 0.049
DIAGRAM: 1-[+10]-164-[+1]-19
[+10]
7.3e-07
CACTCAGTGCCC
+++++++ ++++
1 CCACCCAGGGCCCCGTGGCTGCCCTTGTAAGGAGGCGAGGCCGAGGACACCCGAGACGCCCGGTTATAATTAACC
[+1]
1.3e-06
CTAAAAATAGC
+++++++++++
151 GCGGCAGAGGAGACAGCAAAGCGCCCTCTAAAAATAACTCCTTTCCCGGCGACCGAG
AchR_epsilon
z84811 chr17:5372028-5372312
LENGTH = 284 COMBINED P-VALUE = 2.26e-03 E-VALUE = 0.1
DIAGRAM: 75-[+2]-82-[-6]-18-[-2]-1-[+10]-11-[+14]-41
[+2]
3.2e-05
AGGGGAGGGGG
++++ +++++
76 GGGGCAGGGGCAGGAAACACAGGATGGGGCAGCTGCCTCTGGAAGCAGCCAAAATGTCCCCAGCTGCAGCAGGGG
[-6] [-2] [+10]
5.7e-05 1.8e-06 9.0e-05
ACATACACACT CCCCCTCCCCT CACTCAGTGCCC
+++ +++ + ++ ++++++++ +++ +++ + ++
151 TGAGCAGAGGATTAGGTGACAGTCCCCTAACAGCCCGGAACTAACACCCTCCTCCCCCTCACACAGGCACCCTGG
[+14]
1.8e-05
CCTCCCATCCT
+++++ +++++
226 CATGCCCCCTCCAAGCCTGCCAGAGCTCAGAATAACCCTGAGAACCACGCAGCAGGATG
AchR_delta,
z79611 chr2:243760886-243761056
LENGTH = 170 COMBINED P-VALUE = 2.38e-03 E-VALUE = 0.11
DIAGRAM: 30-[-2]-26-[-10]-26-[-2]-20-[+14]-23
[-2] [-10]
7.4e-05 8.0e-05
CCCCCTCCCCT GGGCACTG
+ +++ ++++ ++ +++++
1 CAGCCTGGGATCTTTGCCTCATGTCCTTGGGCTCCTGCCCTGGCTGGCCCGTCCCCCACCGCCATGAGGTGTCAG
[-2] [+14]
7.8e-07 3.1e-05
AGTG CCCCCTCCCCT CCTCCCATCCT
+ ++ +++++++++++ ++ ++++ +++
76 ATTGTGTTTCCGGCTGCCTCTTCCCGTTGACCCCCTCCTCCCCCAACACCTGTCCCCTCTCCCGCCCACCCTCAT
dystrophin_intron
enhancer u93356 (1...195) chrX:32705157-32705352
LENGTH = 195 COMBINED P-VALUE = 4.30e-03 E-VALUE = 0.2
DIAGRAM: 15-[+3]-5-[+3]-39-[+3]-73-[+7]-16
[+3] [+3]
6.9e-05 5.3e-05
AAAAAAAAGGAA AAAAAAAAGGAA
++++++ ++ ++ +++++ +++++
1 CTAGTTGAGTAAGTGAAAAAATAATAATCTGTAAAAATGATGAATCCCAATGACTCACATGTTGCAAAATAACTA
[+3]
5.8e-05
AAAAAAAAGGAA
+++++++++ ++
76 GGAAGCAAAAGGGAAATTAGACTTTAAAGAGCGTAATCAGATGCAAGAAATGTTGGCTTGTAGGTGGTTAACTAA
[+7]
4.0e-07
CAGAAAGCTGG
+++++++++++
151 AATCGCTTACGGGAAGCTCAGACAGCTGGGGAATCCTGATTTAGT
Desmin_promoter
-228 to +75 m63391chr2:229783548-229783857
LENGTH = 303 COMBINED P-VALUE = 6.15e-03 E-VALUE = 0.28
DIAGRAM: 53-[+11]-35-[-2]-48-[+2]-112-[+14]-11
[+11]
4.3e-06
GCTCCCTGGCT
++ + ++++++
1 ACATGCTTGCTGCCTGCCCTGGCGAAGGATTGGTAGGCTTGCCGTCACAGGACCCCCGCTGGCTGACTCAGGGGC
[-2]
7.0e-05
CCCCCTCCCCT
+ +++ +++++
76 GCAGGCTCTTGCGGGGGAGCTGGCCTCCCGCCCCCACGGCCACGGGCCCTTTCCTGGCAGGACAGCGGGATCTTG
[+2]
1.9e-06
AGGGGAGGGGG
++++++++++
151 CAGCTGTCAGGGGAGGGGAGGCGGGGGCTGATGTCAGGAGGGATACAAATAGTGCCGACGGCTGGGGGCCCTGTC
[+14]
6.3e-05
CCTCCCATCCT
++ +++++++
226 TCCCCTCGCCGCATCCACTCTCCGGCCGGCCGCCTGCCCGCCGCCTCCTCCGTGCGCCCGCCAGCCTCGCCCGCG
dystrophin_promoter
-140...+20 m32058 (740...870) chr11:18004960-18005218
LENGTH = 161 COMBINED P-VALUE = 7.54e-03 E-VALUE = 0.35
DIAGRAM: 70-[+13]-54-[+7]-14
[+13]
3.7e-
AGAGA
+++++
1 GAGCTTGCCATGCTGGAAGCACAACCTTATATGTAGTGACCATGGACAGTCCTATTATGGGAAACCAACTTGAGA
[+7]
06 2.8e-05
TGGGAGG CAGAAAGCTGG
+++++++ +++++ ++++
76 GAGAAGGCGGGTCACTTGCTTGTGCGCAGGTCCTGGAATTTGAAATATCCGGGGGCCTCTACAGAATCCTGGCAT
retinoblastoma
-207...-1 x16439 (695...900) chr13:48232973-48233180
LENGTH = 206 COMBINED P-VALUE = 8.06e-03 E-VALUE = 0.37
DIAGRAM: 176-[+11]-19
[+11]
4.0e-07
GCTCCCTGGCT
++++ ++++++
151 GTCGTCCTCCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTC
skeletal
alpha-actin gene. M20543 chr1:266117022-266117171
LENGTH = 150 COMBINED P-VALUE = 9.03e-03 E-VALUE = 0.42
DIAGRAM: 32-[+2]-81-[+1]-15
[+2]
5.1e-06
AGGGGAGGGGG
+ +++++++++
1 ACCCGGGCGGGGGCCCAGGCCGCGAACCGGCCGAGGGAGGGGGCTCTAGTGCCCAACACCCAAATATGGCTCGAG
[+1]
8.4e-05
CTAAAAATAGC
+++++ +++++
76 AAGGGCAGCGACATTCCTGCGGGGTGGCGCGGAGGGAATCGCCCGCGGGCTATATAAAACCTGAGCAGAGGGACA
MLc1/3
3' enhancer, typed in from Rosenthal chr2:220260389-220260516
LENGTH = 127 COMBINED P-VALUE = 1.27e-02 E-VALUE = 0.58
DIAGRAM: 17-[+3]-75-[+1]-12
[+3]
3.1e-05
AAAAAAAAGGAA
+++++++++ ++
1 CAAGTAACAGCAGGTGCAAAATAAAGTAGCAGGCGGAAGAGTGACAGTAATTTTTAACATCTACACCAGCTGGCA
[+1]
6.1e-06
CTAAAAATAGC
+++++++++++
76 AAAATGACAGGTGCCTAATTCCTCAGTCTTTAAAAATAACTTTTGAGAAGCC
glut4
enhancer, m61126chr17:7864260-7864321
LENGTH = 61 COMBINED P-VALUE = 2.61e-02 E-VALUE = 1.2
DIAGRAM: 14-[+1]-36
[+1]
4.0e-07
CTAAAAATAGC
+++++++++++
1 TCCCAACGTGGGAGCTAAAAATAGCAGCCCCGGGTTACTTTGGGGCATTGCTCCTCTCCCA
AChR_beta
promoter Z79610 chr17:8099980-8100144
LENGTH = 180 COMBINED P-VALUE = 3.13e-02 E-VALUE = 1.4
DIAGRAM: 15-[-5]-53-[+5]-64-[-10]-20
[-5]
3.1e-05
CTGTTGCT
++++++++
1 GGTGGCGGGCTTGGCCAGTTGCTCGAGGCAGGATCAAGTCCCGGGGGCGGGGCGGGTGGGCTGGCGGCTGTCCTC
[+5] [-
1.6e-05 9.
AGCAACAG GG
++++++++ +
76 CAGCAACAGGTGCACATTCCCGGGCTCCTCGTCACTTCCCCTGTGCTGGCGGTCCCAGCGGCTCTCTGAGCGAAG
10]
5e-05
GCACTGAGTG
+++++++ +
151 TCACTGAGCGAGCCGAGCCGCCACGGTATG
Debugging Information
CPU: veggie
Time 0.195970 secs.
mast ../MEME/meme_text_fickett_data_original_anr_15mtfs_8-12_6minsites_revcomp.txt -d ../../Data_sets/Fickett/fickett.data -remcorr
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Links to Entrez database at NCBI
Links to sequence scores (section I)
Links to motif diagrams (section II)
Links to sequence/motif annotated alignments (section III)
This information