******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 3.0 (Release date: 2004/08/18 09:07:01) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.sdsc.edu. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.sdsc.edu. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= ../Sequences/fickett.data ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ AChR_beta 1.0000 180 AchR_gamma 1.0000 389 AchR_delta, 1.0000 170 AchR_epsilon 1.0000 284 Actin, 1.0000 553 McK_enh 1.0000 207 McK_pro 1.0000 718 Desmin_enhancer, 1.0000 126 Desmin_promoter 1.0000 303 glut4 1.0000 61 myogenin 1.0000 286 MLc1/3_3f 1.0000 566 MLc1/3 1.0000 127 MLc1A 1.0000 650 tnc 1.0000 310 tnI_up 1.0000 171 tnI_frst_int 1.0000 197 tnI_prom 1.0000 107 myosin_b 1.0000 101 cardiac 1.0000 386 skeletal 1.0000 150 VSM 1.0000 98 acetylcholinesterase 1.0000 240 neurofilament 1.0000 1029 aMPD3 1.0000 327 aB 1.0000 670 cytochrome 1.0000 300 ventrical/slow 1.0000 313 mlc-2 1.0000 158 myoglobin 1.0000 373 PgaM-M 1.0000 190 retinoblastoma 1.0000 206 ryanodine 1.0000 537 SERca2 1.0000 191 sarcomeric 1.0000 926 Na-K 1.0000 420 sm22-alpha 1.0000 190 aldolase-a 1.0000 278 atrial 1.0000 228 dystrophin_intron 1.0000 195 dystrophin_promoter 1.0000 161 myo-D 1.0000 258 ant1 1.0000 716 enolase_b 1.0000 134 bin1 1.0000 886 mhc_b 1.0000 268 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme ../Sequences/fickett.data -dna -nmotifs 15 -minsites 6 -maxsites 50 -mod anr -revcomp -minw 8 -maxw 12 model: mod= anr nmotifs= 15 evt= inf object function= E-value of product of p-values width: minw= 8 maxw= 12 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 6 maxsites= 50 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 15334 N= 46 strands: + - sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.206 C 0.294 G 0.294 T 0.206 Background letter frequencies (from dataset with add-one prior applied): A 0.206 C 0.294 G 0.294 T 0.206 ******************************************************************************** ******************************************************************************** MOTIF 1 width = 11 sites = 42 llr = 426 E-value = 1.2e-024 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 1:7699a3922 pos.-specific C 7::::::::16 probability G ::::1::1161 matrix T 2a24:1:7::: bits 2.3 2.1 * * 1.8 * * * 1.6 * *** * Information 1.4 * **** * content 1.1 ******** (14.6 bits) 0.9 ******** 0.7 ******** * 0.5 *********** 0.2 *********** 0.0 ----------- Multilevel CTAAAAATAGC consensus T TT A AA sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ----------- MLc1/3_3f + 391 8.21e-08 TTCTGGTCAT CTAAAAATAGC TCTCAGGGTA glut4 + 15 8.21e-08 AACGTGGGAG CTAAAAATAGC AGCCCCGGGT McK_enh + 178 2.22e-07 AAAGCGCCCT CTAAAAATAAC TCCTTTCCCG sarcomeric - 449 3.37e-07 ATAGCCCTGC TTAAAAATAGC CCCGCTTGGG tnc + 217 3.37e-07 TTGTTCCTCG TTAAAAATAGC CCAGTGGCCA MLc1A + 254 4.19e-07 TCGGGAGGGG CTAAAAAAAGC CTCACCCTCC PgaM-M - 16 6.73e-07 AGAGGCTGTG CTTAAAATAGC CCCACGCATC mlc-2 - 88 8.36e-07 CTCCCCATGT TTAAAAATAAC CCCATGACCG MLc1/3 + 105 8.36e-07 TCCTCAGTCT TTAAAAATAAC TTTTGAGAAG mhc_b - 216 1.25e-06 AAGCAAAATG CTATAAATAAA GAGAGGCTGG enolase_b - 89 1.81e-06 GGTGCTGGAG CTAAAAATACC CTACAAAAAG tnI_up + 138 1.81e-06 ATCAACCATC CTAAAAATACC CGGTAAACAG atrial + 126 1.92e-06 AGCTGGGGGG CTATAAAAAGA GGCGGCACTG Desmin_enhancer, + 57 2.62e-06 GCGTTCTCCT CTATAAATACC CGCTCTGGTA cardiac + 155 2.98e-06 TGCCCAAGGA CTAAAAAAAGG CCGTGGAGCC ryanodine - 130 3.28e-06 GATCTCCTGA CTTTAAAAAGC ACCAAACATA cytochrome + 195 5.04e-06 ATAGAAACCC CTAAGAATAGC CGCCAGTGCT Na-K - 326 6.38e-06 AACAGGGTAG CTTTAAATAGG TCCTTCTCCC aldolase-a + 69 7.66e-06 TCAGGTTTCC CTAAATATAGG TCCCTGCCAG cytochrome + 179 7.66e-06 AGGCCCCATT TTAAATATAGA AACCCCTAAG tnI_prom - 31 8.37e-06 CAACTGGCTG GTAAAAATAGA ACAGACCCAC sarcomeric - 403 9.08e-06 GGAAGGCTGC CTGTAAATAGC AATGACCCAG sarcomeric - 139 1.11e-05 CGACCCATGT TTAAAAATATC ATCTATTTTA skeletal + 125 1.11e-05 CGCCCGCGGG CTATATAAAAC CTGAGCAGAG myogenin - 117 1.11e-05 GGAACCAGAG ATAAATATAGC CAACGCCACA ant1 + 399 1.23e-05 GCTGCCTGTG CTATAAATACG CGGCCCACAT cytochrome + 76 1.33e-05 CCCTGCAACT ATATAAAAAGA ATGGCATATT sarcomeric + 42 1.45e-05 TGGTCCCAAT CTTTATATAAC CACCCCAATC dystrophin_intron + 97 1.72e-05 GGAAATTAGA CTTTAAAGAGC GTAATCAGAT MLc1A - 507 2.02e-05 CTGCTGCTGA CTATAAAAGGA AGAAACGCCA aB - 520 2.21e-05 ACTCACTGAG CTAAGAAAAGA GAGACACAAA neurofilament + 925 2.40e-05 GCCTCCCGGC GTATAAATAGG GGTGGCAGAA aB - 104 2.57e-05 ACCCCACCCC CTGAAAAAAGA GCAAACAGAT bin1 + 637 3.01e-05 CGGAGTGGCC CTTTAAAAGGC AGCTTATTGT tnI_frst_int + 10 3.27e-05 GGCAGAGCC CTAAGAATAAG CAGCTGCCCA MLc1/3 - 47 3.27e-05 GGTGTAGATG TTAAAAATTAC TGTCACTCTT myoglobin + 205 4.02e-05 TGGCACCTGC CCTAAAATAGC TTCCCATGTG sarcomeric + 884 4.30e-05 AAGGGCAGTG CTATAAAGGGC CCAGCGCCAC aMPD3 - 206 4.64e-05 AGCAGGGTTG ATTAAAATGGC ATCACAGGGT McK_pro + 679 4.64e-05 CTAGGTCCCC CTATATAAGGC CACGGCTGCT McK_enh + 64 4.64e-05 AGACGCCCGG TTATAATTAAC CAGGACACGT sarcomeric + 162 6.10e-05 ATGGGTCGTG TTTAAAAGAAA TGGAAACTCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- MLc1/3_3f 8.2e-08 390_[+1]_165 glut4 8.2e-08 14_[+1]_36 McK_enh 4.6e-05 63_[+1]_103_[+1]_19 sarcomeric 6.1e-05 41_[+1]_86_[-1]_12_[+1]_230_[-1]_ 35_[-1]_424_[+1]_32 tnc 3.4e-07 216_[+1]_83 MLc1A 2e-05 253_[+1]_242_[-1]_133 PgaM-M 6.7e-07 15_[-1]_164 mlc-2 8.4e-07 87_[-1]_60 MLc1/3 3.3e-05 46_[-1]_47_[+1]_12 mhc_b 1.3e-06 215_[-1]_42 enolase_b 1.8e-06 88_[-1]_35 tnI_up 1.8e-06 137_[+1]_23 atrial 1.9e-06 125_[+1]_92 Desmin_enhancer, 2.6e-06 56_[+1]_59 cardiac 3e-06 154_[+1]_221 ryanodine 3.3e-06 129_[-1]_397 cytochrome 1.3e-05 75_[+1]_92_[+1]_5_[+1]_95 Na-K 6.4e-06 325_[-1]_84 aldolase-a 7.7e-06 68_[+1]_199 tnI_prom 8.4e-06 30_[-1]_66 skeletal 1.1e-05 124_[+1]_15 myogenin 1.1e-05 116_[-1]_159 ant1 1.2e-05 398_[+1]_307 dystrophin_intron 1.7e-05 96_[+1]_88 aB 2.6e-05 103_[-1]_405_[-1]_140 neurofilament 2.4e-05 924_[+1]_94 bin1 3e-05 636_[+1]_239 tnI_frst_int 3.3e-05 9_[+1]_177 myoglobin 4e-05 204_[+1]_158 aMPD3 4.6e-05 205_[-1]_111 McK_pro 4.6e-05 678_[+1]_29 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=11 seqs=42 MLc1/3_3f ( 391) CTAAAAATAGC 1 glut4 ( 15) CTAAAAATAGC 1 McK_enh ( 178) CTAAAAATAAC 1 sarcomeric ( 449) TTAAAAATAGC 1 tnc ( 217) TTAAAAATAGC 1 MLc1A ( 254) CTAAAAAAAGC 1 PgaM-M ( 16) CTTAAAATAGC 1 mlc-2 ( 88) TTAAAAATAAC 1 MLc1/3 ( 105) TTAAAAATAAC 1 mhc_b ( 216) CTATAAATAAA 1 enolase_b ( 89) CTAAAAATACC 1 tnI_up ( 138) CTAAAAATACC 1 atrial ( 126) CTATAAAAAGA 1 Desmin_enhancer, ( 57) CTATAAATACC 1 cardiac ( 155) CTAAAAAAAGG 1 ryanodine ( 130) CTTTAAAAAGC 1 cytochrome ( 195) CTAAGAATAGC 1 Na-K ( 326) CTTTAAATAGG 1 aldolase-a ( 69) CTAAATATAGG 1 cytochrome ( 179) TTAAATATAGA 1 tnI_prom ( 31) GTAAAAATAGA 1 sarcomeric ( 403) CTGTAAATAGC 1 sarcomeric ( 139) TTAAAAATATC 1 skeletal ( 125) CTATATAAAAC 1 myogenin ( 117) ATAAATATAGC 1 ant1 ( 399) CTATAAATACG 1 cytochrome ( 76) ATATAAAAAGA 1 sarcomeric ( 42) CTTTATATAAC 1 dystrophin_intron ( 97) CTTTAAAGAGC 1 MLc1A ( 507) CTATAAAAGGA 1 aB ( 520) CTAAGAAAAGA 1 neurofilament ( 925) GTATAAATAGG 1 aB ( 104) CTGAAAAAAGA 1 bin1 ( 637) CTTTAAAAGGC 1 tnI_frst_int ( 10) CTAAGAATAAG 1 MLc1/3 ( 47) TTAAAAATTAC 1 myoglobin ( 205) CCTAAAATAGC 1 sarcomeric ( 884) CTATAAAGGGC 1 aMPD3 ( 206) ATTAAAATGGC 1 McK_pro ( 679) CTATATAAGGC 1 McK_enh ( 64) TTATAATTAAC 1 sarcomeric ( 162) TTTAAAAGAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 11 n= 14874 bayes= 10.1368 E= 1.2e-024 -153 118 -263 6 -1204 -362 -1204 225 184 -1204 -263 6 153 -1204 -1204 98 217 -1204 -204 -1204 206 -1204 -1204 -53 225 -1204 -1204 -311 35 -1204 -204 170 206 -1204 -130 -311 21 -163 113 -311 6 113 -104 -1204 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 11 nsites= 42 E= 1.2e-024 0.071429 0.666667 0.047619 0.214286 0.000000 0.023810 0.000000 0.976190 0.738095 0.000000 0.047619 0.214286 0.595238 0.000000 0.000000 0.404762 0.928571 0.000000 0.071429 0.000000 0.857143 0.000000 0.000000 0.142857 0.976190 0.000000 0.000000 0.023810 0.261905 0.000000 0.071429 0.666667 0.857143 0.000000 0.119048 0.023810 0.238095 0.095238 0.642857 0.023810 0.214286 0.642857 0.142857 0.000000 -------------------------------------------------------------------------------- Time 79.90 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 width = 11 sites = 47 llr = 443 E-value = 3.6e-015 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A 412::6::111 pos.-specific C ::::2:::::: probability G 598a7:aa988 matrix T :::::3::::: bits 2.3 2.1 1.8 * * 1.6 * ** Information 1.4 * * ** content 1.1 *** ***** (13.6 bits) 0.9 *********** 0.7 *********** 0.5 *********** 0.2 *********** 0.0 ----------- Multilevel GGGGGAGGGGG consensus A A CT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ----------- myoglobin + 288 6.98e-07 GAAGGAGGGC AGGGGAGGGGG ACAGCGAGCC MLc1A + 436 6.98e-07 TGTGGCATGA AGGGGAGGGGG CTGGTGGCCC Actin, - 274 6.98e-07 CATGTAAGGA AGGGGAGGGGG CAGTCAGGGG enolase_b + 42 1.70e-06 TGTTCTGAGT GGGGGAGGGGG CTGCGCCTGC myo-D + 165 1.70e-06 CAGCCAGTGT GGGGGAGGGGG TGGCTGCCTC aB + 427 2.39e-06 TTCAGAGAAC AGGGGTGGGGG TGGGTGCCAT Actin, - 405 2.39e-06 AGCCGGGGGC AGGGGTGGGGG GCCCGGTCTG ant1 + 560 4.58e-06 TCTGCAGCTG GGAGGAGGGGG CGCCCCGCAC SERca2 + 139 4.58e-06 GAGGGAGCCG GGAGGAGGGGG CGGGGCCGCG AchR_delta, - 106 4.58e-06 AGGTGTTGGG GGAGGAGGGGG TCAACGGGAA myoglobin - 124 6.26e-06 TGTGGAAAGA AGGGGAGGAGG TTGGGCACTG Desmin_enhancer, - 1 7.25e-06 AGGAGCTGTG GGGGCAGGGGG AchR_epsilon - 198 9.14e-06 GCCTGTGTGA GGGGGAGGAGG GTGTTAGTTC Desmin_promoter + 159 9.63e-06 TGCAGCTGTC AGGGGAGGGGA GGCGGGGGCT ventrical/slow - 99 1.03e-05 CTGTTGGGAA GGGGGAGGGAG AGAGGGGGAC ryanodine - 518 1.17e-05 CTGGGCGGG AGGGCTGGGGG CGGGCTGGGG bin1 + 852 1.37e-05 ACGCGCGGCC GGGGCTGGGGG CTGGGAGCGC PgaM-M - 57 1.37e-05 TGAGCTGCTG GGGGCTGGGGG CCAGGGGAGT aB + 335 1.91e-05 GGACTGGAAA GGAGGAGGAGG GGCACACTAC sm22-alpha + 72 2.02e-05 TGGGGGAGCC GGGGGTGGGGA GCGGAGCCGG Na-K - 123 2.18e-05 AGAGGCTGCA AGGGAAGGGGG CCTGGGTCCC SERca2 + 125 2.18e-05 CAGGCGCGCG GGAGGAGGGAG CCGGGAGGAG neurofilament - 977 2.18e-05 CAGGGGAGAG AGGGAAGGGGG AGGATGGATG skeletal + 33 2.18e-05 CGAACCGGCC GAGGGAGGGGG CTCTAGTGCC atrial + 114 2.43e-05 GCGTGCTTGG AGAGCTGGGGG GCTATAAAAA Na-K + 291 2.43e-05 CGTTTCTTTC GGAGGAGGGGA AGGCGGGGGA MLc1A - 267 2.43e-05 CACAAAGCCC AGGGGAGGGTG AGGCTTTTTT tnI_frst_int + 181 2.53e-05 TGGCGGAGGC AGAGGTGGAGG GAGGCC McK_pro + 63 2.91e-05 GGTTAAGTGG GGGGGAGGGTG ACCACCGCCT Actin, + 177 2.91e-05 ACCCCAGAAA GGGGGAGGGGT GGGCTGGCGT mlc-2 + 27 3.20e-05 AAGAACGGCA TGGGGTGGGGG GGCCTTAGGT cardiac + 282 3.20e-05 AGGAGGGGAG AGAGGTGGGAG GGAGGGTCCT tnI_frst_int - 134 3.20e-05 CTGGGGTGGA GGAGGTGGAGG TGTAGTGTGA myogenin + 10 3.20e-05 CTGGCAGGG TGGGGTGGGGG CCATGCGGGA Actin, - 321 3.20e-05 CATGGAGCCA AGGGCAGGGGA GAGGATCAGC bin1 - 702 3.47e-05 AGGGAGGGAG AGGGGAGGGGC CGGGCCTCAG Na-K + 306 3.47e-05 AGGGGAAGGC GGGGGAGAGGG GGAGAAGGAC aldolase-a - 6 3.84e-05 GCATGGGGAA GGGGGAGGAAG ACTTG cardiac + 327 3.84e-05 AATTTAGACA GAGGGTGGGGG AAACGGGATA Actin, - 208 3.84e-05 TGAAGGGTAG GGGGCAGGGGA AGACTAAGTG sarcomeric - 608 4.83e-05 GCCCTGAGGA GGGGCTGGAGG GACCTCCTTC McK_pro + 304 4.83e-05 GGACTCGGGT AGGGGTGAGGG CCCAGGGGCG ventrical/slow + 249 5.54e-05 TGTGCACTGC AGGGGTGGGGC TGGGGTCATG acetylcholinesterase + 80 6.41e-05 GAGAGCGGGG AGGGGCGGGGG CGGAGACAGT McK_pro + 592 6.41e-05 GTATGGTGCC GGAGCAGGGAG GTGAGAGGCT aldolase-a + 108 6.84e-05 TGGCGGGAAA AGGGCAGGGGT CATTAGAGAA acetylcholinesterase + 36 6.84e-05 TCTCGGCTCC AAGGGAGGGAG AGAGAGGGGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- myoglobin 6.3e-06 123_[-2]_153_[+2]_75 MLc1A 2.4e-05 266_[-2]_158_[+2]_204 Actin, 3.8e-05 176_[+2]_20_[-2]_55_[-2]_36_[-2]_ 73_[-2]_138 enolase_b 1.7e-06 41_[+2]_82 myo-D 1.7e-06 164_[+2]_83 aB 1.9e-05 334_[+2]_81_[+2]_233 ant1 4.6e-06 559_[+2]_146 SERca2 2.2e-05 124_[+2]_3_[+2]_42 AchR_delta, 4.6e-06 105_[-2]_54 Desmin_enhancer, 7.3e-06 [-2]_115 AchR_epsilon 9.1e-06 197_[-2]_76 Desmin_promoter 9.6e-06 158_[+2]_134 ventrical/slow 5.5e-05 98_[-2]_139_[+2]_54 ryanodine 1.2e-05 517_[-2]_9 bin1 3.5e-05 701_[-2]_139_[+2]_24 PgaM-M 1.4e-05 56_[-2]_123 sm22-alpha 2e-05 71_[+2]_108 Na-K 2.4e-05 122_[-2]_157_[+2]_4_[+2]_104 neurofilament 2.2e-05 976_[-2]_42 skeletal 2.2e-05 32_[+2]_107 atrial 2.4e-05 113_[+2]_104 tnI_frst_int 3.2e-05 133_[-2]_36_[+2]_6 McK_pro 4.8e-05 62_[+2]_230_[+2]_277_[+2]_116 mlc-2 3.2e-05 26_[+2]_121 cardiac 3.8e-05 281_[+2]_34_[+2]_49 myogenin 3.2e-05 9_[+2]_266 aldolase-a 6.8e-05 5_[-2]_91_[+2]_160 sarcomeric 4.8e-05 607_[-2]_308 acetylcholinesterase 6.4e-05 35_[+2]_33_[+2]_150 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=11 seqs=47 myoglobin ( 288) AGGGGAGGGGG 1 MLc1A ( 436) AGGGGAGGGGG 1 Actin, ( 274) AGGGGAGGGGG 1 enolase_b ( 42) GGGGGAGGGGG 1 myo-D ( 165) GGGGGAGGGGG 1 aB ( 427) AGGGGTGGGGG 1 Actin, ( 405) AGGGGTGGGGG 1 ant1 ( 560) GGAGGAGGGGG 1 SERca2 ( 139) GGAGGAGGGGG 1 AchR_delta, ( 106) GGAGGAGGGGG 1 myoglobin ( 124) AGGGGAGGAGG 1 Desmin_enhancer, ( 1) GGGGCAGGGGG 1 AchR_epsilon ( 198) GGGGGAGGAGG 1 Desmin_promoter ( 159) AGGGGAGGGGA 1 ventrical/slow ( 99) GGGGGAGGGAG 1 ryanodine ( 518) AGGGCTGGGGG 1 bin1 ( 852) GGGGCTGGGGG 1 PgaM-M ( 57) GGGGCTGGGGG 1 aB ( 335) GGAGGAGGAGG 1 sm22-alpha ( 72) GGGGGTGGGGA 1 Na-K ( 123) AGGGAAGGGGG 1 SERca2 ( 125) GGAGGAGGGAG 1 neurofilament ( 977) AGGGAAGGGGG 1 skeletal ( 33) GAGGGAGGGGG 1 atrial ( 114) AGAGCTGGGGG 1 Na-K ( 291) GGAGGAGGGGA 1 MLc1A ( 267) AGGGGAGGGTG 1 tnI_frst_int ( 181) AGAGGTGGAGG 1 McK_pro ( 63) GGGGGAGGGTG 1 Actin, ( 177) GGGGGAGGGGT 1 mlc-2 ( 27) TGGGGTGGGGG 1 cardiac ( 282) AGAGGTGGGAG 1 tnI_frst_int ( 134) GGAGGTGGAGG 1 myogenin ( 10) TGGGGTGGGGG 1 Actin, ( 321) AGGGCAGGGGA 1 bin1 ( 702) AGGGGAGGGGC 1 Na-K ( 306) GGGGGAGAGGG 1 aldolase-a ( 6) GGGGGAGGAAG 1 cardiac ( 327) GAGGGTGGGGG 1 Actin, ( 208) GGGGCAGGGGA 1 sarcomeric ( 608) GGGGCTGGAGG 1 McK_pro ( 304) AGGGGTGAGGG 1 ventrical/slow ( 249) AGGGGTGGGGC 1 acetylcholinesterase ( 80) AGGGGCGGGGG 1 McK_pro ( 592) GGAGCAGGGAG 1 aldolase-a ( 108) AGGGCAGGGGT 1 acetylcholinesterase ( 36) AAGGGAGGGAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 11 n= 14874 bayes= 9.01979 E= 3.6e-015 112 -1220 80 -227 -169 -1220 167 -1220 19 -1220 138 -1220 -1220 -1220 177 -1220 -227 -47 134 -1220 163 -379 -1220 73 -1220 -1220 177 -1220 -227 -1220 170 -1220 -47 -1220 153 -1220 -69 -1220 150 -227 -95 -279 146 -227 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 11 nsites= 47 E= 3.6e-015 0.446809 0.000000 0.510638 0.042553 0.063830 0.000000 0.936170 0.000000 0.234043 0.000000 0.765957 0.000000 0.000000 0.000000 1.000000 0.000000 0.042553 0.212766 0.744681 0.000000 0.638298 0.021277 0.000000 0.340426 0.000000 0.000000 1.000000 0.000000 0.042553 0.000000 0.957447 0.000000 0.148936 0.000000 0.851064 0.000000 0.127660 0.000000 0.829787 0.042553 0.106383 0.042553 0.808511 0.042553 -------------------------------------------------------------------------------- Time 157.65 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 width = 12 sites = 28 llr = 276 E-value = 7.2e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A aa5447683:95 pos.-specific C :::::::::::: probability G ::55313158:4 matrix T :::1211:3211 bits 2.3 ** 2.1 ** 1.8 ** * 1.6 ** * Information 1.4 ** * * content 1.1 *** * * ** (14.2 bits) 0.9 *** * * ** 0.7 **** *** *** 0.5 ************ 0.2 ************ 0.0 ------------ Multilevel AAAGAAAAGGAA consensus GAG G T G sequence T A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ------------ neurofilament + 364 6.89e-08 GCAGCTCATT AAAGAAAAAGAA AAATAAATCA ant1 + 104 1.02e-06 CGATTGAATG AAAAGAAATGAG AGGCAGCAGG mhc_b - 240 1.57e-06 AAGTGATAGC AAGATAAAGGAG AGCAAGCAAA MLc1/3_3f + 518 1.57e-06 GCTTGCCCAG AAATAAAAGGAA GCCTCAGCCA neurofilament + 717 1.88e-06 GTGAGTACAG AAGGGAAATGAG TGAGGGGGCA neurofilament + 391 1.88e-06 AATCAGGAGA AAGGAAGATGAA TTGCAGAAAG MLc1/3 + 18 3.99e-06 CAGCAGGTGC AAAATAAAGTAG CAGGCGGAAG neurofilament + 532 6.56e-06 ACCAAGGGAA AAAATTAAGGAG GTTCCTGGTG mhc_b - 153 7.31e-06 TAAGGCCCTG AAGTGAAAGGAA GGTGATCTGC dystrophin_intron + 33 7.31e-06 AATAATCTGT AAAAATGATGAA TCCCAATGAC dystrophin_intron + 84 8.21e-06 TAGGAAGCAA AAGGGAAATTAG ACTTTAAAGA myoglobin + 236 8.21e-06 AGGGCTAGAG AAAGGAAAAGAT TAGACCCTCC dystrophin_intron + 16 9.98e-06 TGAGTAAGTG AAAAAATAATAA TCTGTAAAAA sarcomeric + 125 9.98e-06 ACCCCATGCA AAGGTAAAATAG ATGATATTTT myoglobin + 273 9.98e-06 TGAGAGAGAG AAAGTGAAGGAG GGCAGGGGAG myogenin + 32 1.23e-05 CATGCGGGAG AAAGAAGGGGAA TCACATCTAA bin1 - 405 1.34e-05 TTTCGAAATC AAAGAAAAAGTG CGGCGAAGGG ant1 + 268 1.56e-05 CTTTAGATGC AAGAAGGAGGAA ACAGCTCGAA sarcomeric + 9 1.86e-05 ACTCCTTA AAGGATTATGAA ATTAATTTGA MLc1A + 577 1.86e-05 CCCAGGATAA AAGGGAAGGGAG GCAGCCCAGG cardiac + 258 2.59e-05 CAAAGGATCA AAGGAGGAGGAG CCAGGAGGGG sarcomeric + 283 3.09e-05 CTCGAGAAGG AAGAGACAGGAA CCAATTGGTC neurofilament + 195 3.09e-05 ATTCTCAGTT AAGAAATGTGAA AATCTAGAAA atrial + 178 3.37e-05 GACGTAGGCC AAGAGAGGGGAA CCAGAGAGGA MLc1/3_3f + 439 3.93e-05 TTGCCCTAAG AAAGCTAAAGAA CTCTCCAAGG cardiac + 44 4.52e-05 CTTCGGGGGA AAAATAACTGAG GTAAGGGCCA MLc1/3_3f - 419 4.52e-05 TTCTTAGGGC AAAGGGAAAGAT GGATCTGTAC Na-K + 18 4.86e-05 CCCACTTGGA AAAGAAGAGTTA GGCCACATGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- neurofilament 3.1e-05 194_[+3]_157_[+3]_15_[+3]_129_[+3]_ 173_[+3]_301 ant1 1.6e-05 103_[+3]_152_[+3]_437 mhc_b 7.3e-06 152_[-3]_75_[-3]_17 MLc1/3_3f 3.9e-05 418_[-3]_8_[+3]_67_[+3]_37 MLc1/3 4e-06 17_[+3]_98 dystrophin_intron 7.3e-06 15_[+3]_5_[+3]_39_[+3]_100 myoglobin 1e-05 235_[+3]_25_[+3]_89 sarcomeric 1.9e-05 8_[+3]_104_[+3]_146_[+3]_632 myogenin 1.2e-05 31_[+3]_243 bin1 1.3e-05 404_[-3]_470 MLc1A 1.9e-05 576_[+3]_62 cardiac 2.6e-05 43_[+3]_202_[+3]_117 atrial 3.4e-05 177_[+3]_39 Na-K 4.9e-05 17_[+3]_391 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=12 seqs=28 neurofilament ( 364) AAAGAAAAAGAA 1 ant1 ( 104) AAAAGAAATGAG 1 mhc_b ( 240) AAGATAAAGGAG 1 MLc1/3_3f ( 518) AAATAAAAGGAA 1 neurofilament ( 717) AAGGGAAATGAG 1 neurofilament ( 391) AAGGAAGATGAA 1 MLc1/3 ( 18) AAAATAAAGTAG 1 neurofilament ( 532) AAAATTAAGGAG 1 mhc_b ( 153) AAGTGAAAGGAA 1 dystrophin_intron ( 33) AAAAATGATGAA 1 dystrophin_intron ( 84) AAGGGAAATTAG 1 myoglobin ( 236) AAAGGAAAAGAT 1 dystrophin_intron ( 16) AAAAAATAATAA 1 sarcomeric ( 125) AAGGTAAAATAG 1 myoglobin ( 273) AAAGTGAAGGAG 1 myogenin ( 32) AAAGAAGGGGAA 1 bin1 ( 405) AAAGAAAAAGTG 1 ant1 ( 268) AAGAAGGAGGAA 1 sarcomeric ( 9) AAGGATTATGAA 1 MLc1A ( 577) AAGGGAAGGGAG 1 cardiac ( 258) AAGGAGGAGGAG 1 sarcomeric ( 283) AAGAGACAGGAA 1 neurofilament ( 195) AAGAAATGTGAA 1 atrial ( 178) AAGAGAGGGGAA 1 MLc1/3_3f ( 439) AAAGCTAAAGAA 1 cardiac ( 44) AAAATAACTGAG 1 MLc1/3_3f ( 419) AAAGGGAAAGAT 1 Na-K ( 18) AAAGAAGAGTTA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 14828 bayes= 10.4765 E= 7.2e+001 228 -1145 -1145 -1145 228 -1145 -1145 -1145 138 -1145 66 -1145 93 -1145 86 -153 106 -304 13 6 179 -1145 -104 -53 156 -304 -23 -94 200 -304 -104 -1145 28 -1145 66 47 -1145 -1145 148 -21 217 -1145 -1145 -153 128 -1145 54 -153 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 28 E= 7.2e+001 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.535714 0.000000 0.464286 0.000000 0.392857 0.000000 0.535714 0.071429 0.428571 0.035714 0.321429 0.214286 0.714286 0.000000 0.142857 0.142857 0.607143 0.035714 0.250000 0.107143 0.821429 0.035714 0.142857 0.000000 0.250000 0.000000 0.464286 0.285714 0.000000 0.000000 0.821429 0.178571 0.928571 0.000000 0.000000 0.071429 0.500000 0.000000 0.428571 0.071429 -------------------------------------------------------------------------------- Time 233.32 secs. ******************************************************************************** ******************************************************************************** MOTIF 4 width = 8 sites = 11 llr = 112 E-value = 4.5e+005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 4 Description -------------------------------------------------------------------------------- Simplified A 7aa:9a9: pos.-specific C 1::2:::: probability G :::2:::: matrix T 2::61:1a bits 2.3 ** * * 2.1 ** * * 1.8 ** **** 1.6 ** **** Information 1.4 ** **** content 1.1 *** **** (14.7 bits) 0.9 *** **** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AAATAAAT consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- -------- neurofilament - 477 3.23e-06 TTTTAGATAC AAATAAAT AGGCTAGGTT neurofilament + 376 3.23e-06 AGAAAAAGAA AAATAAAT CAGGAGAAAG bin1 + 150 6.45e-06 GTTGTTATTA TAATAAAT TTTTAGCGAA cytochrome - 6 6.45e-06 AGTTGGGCTT TAATAAAT ATTTG sarcomeric + 744 1.57e-05 GAGAAGAGAG AAACAAAT CCCCCAACAG neurofilament + 427 1.57e-05 AGAAAGCTAG AAAGAAAT TAAAATCTTC MLc1/3_3f + 272 1.57e-05 TTCTGCCATC AAACAAAT AGGAAGCTTC MLc1/3_3f + 245 1.57e-05 CCAAGACCTT AAAGAAAT CCTAAGCTCT sarcomeric - 21 2.21e-05 GGGACCAATC AAATTAAT TTCATAATCC retinoblastoma - 95 2.21e-05 CCCGTTACAA AAATAATT TCAACGTCCC mlc-2 - 114 2.67e-05 AGCCCAGGAA CAATAAAT ACTTCCTCCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- neurofilament 3.2e-06 375_[+4]_43_[+4]_42_[-4]_545 bin1 6.5e-06 149_[+4]_729 cytochrome 6.5e-06 5_[-4]_287 sarcomeric 2.2e-05 20_[-4]_715_[+4]_175 MLc1/3_3f 1.6e-05 244_[+4]_19_[+4]_287 retinoblastoma 2.2e-05 94_[-4]_104 mlc-2 2.7e-05 113_[-4]_37 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 4 width=8 seqs=11 neurofilament ( 477) AAATAAAT 1 neurofilament ( 376) AAATAAAT 1 bin1 ( 150) TAATAAAT 1 cytochrome ( 6) TAATAAAT 1 sarcomeric ( 744) AAACAAAT 1 neurofilament ( 427) AAAGAAAT 1 MLc1/3_3f ( 272) AAACAAAT 1 MLc1/3_3f ( 245) AAAGAAAT 1 sarcomeric ( 21) AAATTAAT 1 retinoblastoma ( 95) AAATAATT 1 mlc-2 ( 114) CAATAAAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 15012 bayes= 10.312 E= 4.5e+005 182 -169 -1010 -18 228 -1010 -1010 -1010 228 -1010 -1010 -1010 -1010 -69 -69 163 214 -1010 -1010 -118 228 -1010 -1010 -1010 214 -1010 -1010 -118 -1010 -1010 -1010 228 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 11 E= 4.5e+005 0.727273 0.090909 0.000000 0.181818 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.181818 0.181818 0.636364 0.909091 0.000000 0.000000 0.090909 1.000000 0.000000 0.000000 0.000000 0.909091 0.000000 0.000000 0.090909 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- Time 307.86 secs. ******************************************************************************** ******************************************************************************** MOTIF 5 width = 8 sites = 9 llr = 95 E-value = 5.3e+005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 5 Description -------------------------------------------------------------------------------- Simplified A a::aa:7: pos.-specific C ::a::a:: probability G :a:::::a matrix T ::::::3: bits 2.3 * ** 2.1 * ** 1.8 ****** * 1.6 ****** * Information 1.4 ******** content 1.1 ******** (15.3 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AGCAACAG consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- -------- Na-K - 342 1.34e-05 AGAAAGCCAA AGCAACAG GGTAGCTTTA MLc1A - 125 1.34e-05 GGAGCTCTGA AGCAACAG CTGGTCCAGC myogenin + 78 1.34e-05 CTTGATGTGC AGCAACAG CTTAGAGGGG Desmin_enhancer, - 92 1.34e-05 TCTCCCTGGC AGCAACAG CTGCCAACCC Actin, - 18 1.34e-05 GCGGCAGGGG AGCAACAG CGGCTTCTCA AChR_beta + 77 1.34e-05 GCTGTCCTCC AGCAACAG GTGCACATTC tnI_prom - 46 2.69e-05 TGTGTCCAGC AGCAACTG GCTGGTAAAA MLc1A - 525 2.69e-05 TGAAAGCAAG AGCAACTG CTGCTGACTA AChR_beta - 16 2.69e-05 TCCTGCCTCG AGCAACTG GCCAAGCCCG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- Na-K 1.3e-05 341_[-5]_71 MLc1A 2.7e-05 124_[-5]_392_[-5]_118 myogenin 1.3e-05 77_[+5]_201 Desmin_enhancer, 1.3e-05 91_[-5]_27 Actin, 1.3e-05 17_[-5]_528 AChR_beta 2.7e-05 15_[-5]_53_[+5]_96 tnI_prom 2.7e-05 45_[-5]_54 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 5 width=8 seqs=9 Na-K ( 342) AGCAACAG 1 MLc1A ( 125) AGCAACAG 1 myogenin ( 78) AGCAACAG 1 Desmin_enhancer, ( 92) AGCAACAG 1 Actin, ( 18) AGCAACAG 1 AChR_beta ( 77) AGCAACAG 1 tnI_prom ( 46) AGCAACTG 1 MLc1A ( 525) AGCAACTG 1 AChR_beta ( 16) AGCAACTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 15012 bayes= 11.1507 E= 5.3e+005 228 -982 -982 -982 -982 -982 176 -982 -982 176 -982 -982 228 -982 -982 -982 228 -982 -982 -982 -982 176 -982 -982 169 -982 -982 69 -982 -982 176 -982 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 9 E= 5.3e+005 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.666667 0.000000 0.000000 0.333333 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- Time 381.53 secs. ******************************************************************************** ******************************************************************************** MOTIF 6 width = 11 sites = 9 llr = 106 E-value = 8.3e+005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 6 Description -------------------------------------------------------------------------------- Simplified A 71::::13::: pos.-specific C :::::::2::: probability G :91a3a:41a: matrix T 3:9:7:9:9:a bits 2.3 * 2.1 * 1.8 ** ** *** 1.6 ** ** *** Information 1.4 **** ** *** content 1.1 ******* *** (17.1 bits) 0.9 ******* *** 0.7 ******* *** 0.5 *********** 0.2 *********** 0.0 ----------- Multilevel AGTGTGTGTGT consensus T G A sequence C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 6 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ----------- ventrical/slow + 45 2.85e-07 TGTGCAGATG AGTGTGTGTGT ATGTGTGTAT neurofilament + 293 2.85e-07 CAGTTTCACG AGTGTGTGTGT GTGTGTGTGT ventrical/slow + 57 4.02e-07 TGTGTGTGTA TGTGTGTATGT GTGTGTTAAG ventrical/slow + 19 1.56e-06 CAGGGCCCTG TGTGGGTATGT GCGGGTGTGC tnI_prom + 20 2.16e-06 AGGAGGGGGC AGTGGGTCTGT TCTATTTTTA aldolase-a + 40 2.27e-06 GCCCCACGAT AGTGTGAATGT CAGGGGCTTC neurofilament - 146 3.81e-06 AACGTGTTGC AGTGTGTGGGT GGTGAGGGCA aMPD3 + 136 5.17e-06 ACTGGGAGGC TATGTGTCTGT TCTGAGCCTT acetylcholinesterase + 135 8.15e-06 TGAGGCCCGG AGGGGGTGTGT GCGGGGGCCG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 6 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- ventrical/slow 4e-07 18_[+6]_15_[+6]_1_[+6]_246 neurofilament 3.8e-06 145_[-6]_136_[+6]_726 tnI_prom 2.2e-06 19_[+6]_77 aldolase-a 2.3e-06 39_[+6]_228 aMPD3 5.2e-06 135_[+6]_181 acetylcholinesterase 8.2e-06 134_[+6]_95 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 6 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 6 width=11 seqs=9 ventrical/slow ( 45) AGTGTGTGTGT 1 neurofilament ( 293) AGTGTGTGTGT 1 ventrical/slow ( 57) TGTGTGTATGT 1 ventrical/slow ( 19) TGTGGGTATGT 1 tnI_prom ( 20) AGTGGGTCTGT 1 aldolase-a ( 40) AGTGTGAATGT 1 neurofilament ( 146) AGTGTGTGGGT 1 aMPD3 ( 136) TATGTGTCTGT 1 acetylcholinesterase ( 135) AGGGGGTGTGT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 6 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 11 n= 14874 bayes= 11.1374 E= 8.3e+005 169 -982 -982 69 -89 -982 159 -982 -982 -982 -140 211 -982 -982 176 -982 -982 -982 18 169 -982 -982 176 -982 -89 -982 -982 211 69 -40 59 -982 -982 -982 -140 211 -982 -982 176 -982 -982 -982 -982 228 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 6 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 11 nsites= 9 E= 8.3e+005 0.666667 0.000000 0.000000 0.333333 0.111111 0.000000 0.888889 0.000000 0.000000 0.000000 0.111111 0.888889 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.333333 0.666667 0.000000 0.000000 1.000000 0.000000 0.111111 0.000000 0.000000 0.888889 0.333333 0.222222 0.444444 0.000000 0.000000 0.000000 0.111111 0.888889 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- Time 455.08 secs. ******************************************************************************** ******************************************************************************** MOTIF 7 width = 11 sites = 16 llr = 171 E-value = 5.8e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif 7 Description -------------------------------------------------------------------------------- Simplified A :9:9591::22 pos.-specific C a:314:19::: probability G ::7:1:8::88 matrix T :1::11:1a:1 bits 2.3 * 2.1 * * * 1.8 ** * * 1.6 ** * * * Information 1.4 ** * * ** content 1.1 ** * * *** (15.4 bits) 0.9 **** ****** 0.7 **** ****** 0.5 *********** 0.2 *********** 0.0 ----------- Multilevel CAGAAAGCTGG consensus C C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 7 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ----------- dystrophin_intron + 169 5.82e-07 ACGGGAAGCT CAGACAGCTGG GGAATCCTGA AchR_gamma + 256 5.82e-07 ACGCTGTGGT CAGACAGCTGG TGGGGCTGGG myo-D + 100 8.21e-07 AGCAGCTGGT CACAAAGCTGG TTAATCTCCC aB + 458 1.16e-06 TGGGTGTGGA CAGAAAGCTAG TGAAACAAGA neurofilament + 416 1.16e-06 CAGAAAGTGC CAGAAAGCTAG AAAGAAATTA cardiac - 106 2.79e-06 GGCTGATGAG CAGATAGCTGG GAAGACAGGA mlc-2 + 133 4.10e-06 TCCTGGGCTG CAGAGAGCTGG GCGGAGTGTG cytochrome - 138 5.87e-06 AGGTCATCTC CAGACAGCTGT TGTCCTGTGC sarcomeric + 546 7.58e-06 TGATCTTGAA CAGAAACCTGA CTGTAATTGT myogenin - 98 7.58e-06 GCCAACGCCA CAGAAACCTGA GCCCCCTCTA Actin, - 42 1.05e-05 CTGAGGGGTC CTGACAGCTGG GCCAGGGCGG neurofilament + 602 1.10e-05 TGACGGGATA CAGAAAACTAG GGTGTCAAAA AchR_gamma - 214 1.20e-05 CCAGGATGGA CACAATGCTGG GCTCAGGTTA cytochrome - 18 1.46e-05 TGGTGGCTGG CACACAGTTGG GCTTTAATAA AchR_gamma + 64 1.46e-05 TTCCCTACCA CACCCAGCTGG CCCTGGCTGT McK_pro - 490 1.96e-05 CTCACGCCCC CACCAAGCTGA TACCCTAACC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 7 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- dystrophin_intron 5.8e-07 168_[+7]_16 AchR_gamma 1.2e-05 63_[+7]_139_[-7]_31_[+7]_123 myo-D 8.2e-07 99_[+7]_148 aB 1.2e-06 457_[+7]_202 neurofilament 1.1e-05 415_[+7]_175_[+7]_417 cardiac 2.8e-06 105_[-7]_270 mlc-2 4.1e-06 132_[+7]_15 cytochrome 1.5e-05 17_[-7]_109_[-7]_152 sarcomeric 7.6e-06 545_[+7]_370 myogenin 7.6e-06 97_[-7]_178 Actin, 1e-05 41_[-7]_501 McK_pro 2e-05 489_[-7]_218 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 7 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 7 width=11 seqs=16 dystrophin_intron ( 169) CAGACAGCTGG 1 AchR_gamma ( 256) CAGACAGCTGG 1 myo-D ( 100) CACAAAGCTGG 1 aB ( 458) CAGAAAGCTAG 1 neurofilament ( 416) CAGAAAGCTAG 1 cardiac ( 106) CAGATAGCTGG 1 mlc-2 ( 133) CAGAGAGCTGG 1 cytochrome ( 138) CAGACAGCTGT 1 sarcomeric ( 546) CAGAAACCTGA 1 myogenin ( 98) CAGAAACCTGA 1 Actin, ( 42) CTGACAGCTGG 1 neurofilament ( 602) CAGAAAACTAG 1 AchR_gamma ( 214) CACAATGCTGG 1 cytochrome ( 18) CACACAGTTGG 1 AchR_gamma ( 64) CACCCAGCTGG 1 McK_pro ( 490) CACCAAGCTGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 7 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 11 n= 14874 bayes= 10.8597 E= 5.8e+003 -1064 176 -1064 -1064 219 -1064 -1064 -172 -1064 9 122 -1064 209 -123 -1064 -1064 128 35 -223 -172 219 -1064 -1064 -172 -172 -123 147 -1064 -1064 167 -1064 -172 -1064 -1064 -1064 228 -13 -1064 147 -1064 -13 -1064 135 -172 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 7 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 11 nsites= 16 E= 5.8e+003 0.000000 1.000000 0.000000 0.000000 0.937500 0.000000 0.000000 0.062500 0.000000 0.312500 0.687500 0.000000 0.875000 0.125000 0.000000 0.000000 0.500000 0.375000 0.062500 0.062500 0.937500 0.000000 0.000000 0.062500 0.062500 0.125000 0.812500 0.000000 0.000000 0.937500 0.000000 0.062500 0.000000 0.000000 0.000000 1.000000 0.187500 0.000000 0.812500 0.000000 0.187500 0.000000 0.750000 0.062500 -------------------------------------------------------------------------------- Time 527.71 secs. ******************************************************************************** ******************************************************************************** MOTIF 8 width = 12 sites = 9 llr = 112 E-value = 4.1e+005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 8 Description -------------------------------------------------------------------------------- Simplified A :2:::::a:1:a pos.-specific C a279::3::9a: probability G ::3::46:a::: matrix T :6:1a61::::: bits 2.3 * * * 2.1 * * * 1.8 * * ** ** 1.6 * * ** ** Information 1.4 * ** ***** content 1.1 * *** ***** (17.9 bits) 0.9 * **** ***** 0.7 ****** ***** 0.5 ************ 0.2 ************ 0.0 ------------ Multilevel CTCCTTGAGCCA consensus AG GC sequence C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 8 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ------------ McK_pro - 358 1.41e-07 GCCCCTGAGT CTCCTTCAGCCA CCAGCCCTTC McK_pro + 256 2.41e-07 GTATCTGCTC CTCCTGGAGCCA CACCTTGGTT Actin, + 467 2.41e-07 TAAAGCGGCC CTCCTGGAGCCA GCCACCCAGA sarcomeric + 637 8.04e-07 GCCCGGTCAG CTGCTGGAGCCA GGCAGCTTGA Na-K + 73 1.35e-06 GTCAACTGCT CCCCTTCAGCCA GATCCTAGGG neurofilament - 850 1.35e-06 GGGCAGCGCG CTGCTGCAGCCA AGGCGAGGAT Na-K - 230 2.90e-06 TCCCCTCCCG CCCCTTTAGCCA CTGGCCCTAG myosin_b + 55 3.00e-06 ATTTTTGCTG CACTTTGAGCCA CCCCGCCCCC sarcomeric + 651 4.46e-06 TGGAGCCAGG CAGCTTGAGACA TCCTCCTCTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 8 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- McK_pro 1.4e-07 255_[+8]_90_[-8]_349 Actin, 2.4e-07 466_[+8]_75 sarcomeric 4.5e-06 636_[+8]_2_[+8]_264 Na-K 2.9e-06 72_[+8]_145_[-8]_179 neurofilament 1.3e-06 849_[-8]_168 myosin_b 3e-06 54_[+8]_35 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 8 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 8 width=12 seqs=9 McK_pro ( 358) CTCCTTCAGCCA 1 McK_pro ( 256) CTCCTGGAGCCA 1 Actin, ( 467) CTCCTGGAGCCA 1 sarcomeric ( 637) CTGCTGGAGCCA 1 Na-K ( 73) CCCCTTCAGCCA 1 neurofilament ( 850) CTGCTGCAGCCA 1 Na-K ( 230) CCCCTTTAGCCA 1 myosin_b ( 55) CACTTTGAGCCA 1 sarcomeric ( 651) CAGCTTGAGACA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 8 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 14828 bayes= 11.1329 E= 4.1e+005 -982 176 -982 -982 11 -40 -982 143 -982 118 18 -982 -982 159 -982 -89 -982 -982 -982 228 -982 -982 59 143 -982 18 92 -89 228 -982 -982 -982 -982 -982 176 -982 -89 159 -982 -982 -982 176 -982 -982 228 -982 -982 -982 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 8 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 9 E= 4.1e+005 0.000000 1.000000 0.000000 0.000000 0.222222 0.222222 0.000000 0.555556 0.000000 0.666667 0.333333 0.000000 0.000000 0.888889 0.000000 0.111111 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.444444 0.555556 0.000000 0.333333 0.555556 0.111111 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.111111 0.888889 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- Time 599.59 secs. ******************************************************************************** ******************************************************************************** MOTIF 9 width = 12 sites = 18 llr = 195 E-value = 1.2e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif 9 Description -------------------------------------------------------------------------------- Simplified A 1::2::2:6::2 pos.-specific C :18::::22::: probability G 9922aa88:aa8 matrix T :::7::1:3::: bits 2.3 2.1 1.8 ** ** 1.6 ** ** Information 1.4 ** ** ** content 1.1 *** ** * *** (15.6 bits) 0.9 ******** *** 0.7 ************ 0.5 ************ 0.2 ************ 0.0 ------------ Multilevel GGCTGGGGAGGG consensus T A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 9 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ------------ PgaM-M + 121 4.11e-07 ATTGGCAGTT GGCTGGGGTGGG TGGGGGCTGG AchR_gamma + 302 4.11e-07 TGGCTGGGCT GGCTGGGGTGGG AGTGTAGGCT AchR_gamma - 188 6.98e-07 AGGTTACCTG GGCTGGAGAGGG GAGACAGGGG tnI_frst_int - 145 1.34e-06 GGGAGGGTAA GGCTGGGGTGGA GGAGGTGGAG AchR_epsilon + 67 1.34e-06 AAGGACGCTG GGCTGGGGCGGG GCAGGGGCAG retinoblastoma + 54 2.19e-06 TCAGTTGCCG GGCGGGGGAGGG CGCGTCCGGT Actin, - 237 2.19e-06 CCAAATAGGG AGCTGGGGAGGG GCAGGCGCTG ventrical/slow - 177 2.84e-06 CTATTTTGGG GCCTGGGGAGGG CATTGTTCAG myosin_b - 1 4.33e-06 TTCCACAGCT GGCAGGAGAGGG aldolase-a + 147 4.62e-06 ACACATGTGG GGCTGGGCAGGA GCTGCCTTAT AchR_delta, - 130 6.47e-06 AATGAGGGTG GGCGGGAGAGGG GACAGGTGTT Na-K + 392 7.16e-06 GTCCCAGACG GGCTGGTGTGGG CTTGGGATCC ant1 - 505 8.57e-06 CCGGGAGCGA GGCTGGGCCGGG GGCTGTCCCT acetylcholinesterase + 102 9.81e-06 GGAGACAGTG GGCGGGGGCGGG CGGGGGCGCT aB - 277 1.40e-05 ACTATCTTGG GCCTGGGCAGGG ACTGGAATCT mhc_b + 126 1.50e-05 GCACAATGCG GGGAGGGGAGGA CCGGGGCAGA Na-K + 243 1.50e-05 CTAAAGGGGC GGGAGGGGAGGA GTCCTCAGGG ryanodine - 298 1.83e-05 TGGCCGCCGG AGGTGGGGTGGG AGAGAGAGTA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 9 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- PgaM-M 4.1e-07 120_[+9]_58 AchR_gamma 7e-07 187_[-9]_102_[+9]_76 tnI_frst_int 1.3e-06 144_[-9]_41 AchR_epsilon 1.3e-06 66_[+9]_206 retinoblastoma 2.2e-06 53_[+9]_141 Actin, 2.2e-06 236_[-9]_305 ventrical/slow 2.8e-06 176_[-9]_125 myosin_b 4.3e-06 [-9]_89 aldolase-a 4.6e-06 146_[+9]_120 AchR_delta, 6.5e-06 129_[-9]_29 Na-K 1.5e-05 242_[+9]_137_[+9]_17 ant1 8.6e-06 504_[-9]_200 acetylcholinesterase 9.8e-06 101_[+9]_127 aB 1.4e-05 276_[-9]_382 mhc_b 1.5e-05 125_[+9]_131 ryanodine 1.8e-05 297_[-9]_228 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 9 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 9 width=12 seqs=18 PgaM-M ( 121) GGCTGGGGTGGG 1 AchR_gamma ( 302) GGCTGGGGTGGG 1 AchR_gamma ( 188) GGCTGGAGAGGG 1 tnI_frst_int ( 145) GGCTGGGGTGGA 1 AchR_epsilon ( 67) GGCTGGGGCGGG 1 retinoblastoma ( 54) GGCGGGGGAGGG 1 Actin, ( 237) AGCTGGGGAGGG 1 ventrical/slow ( 177) GCCTGGGGAGGG 1 myosin_b ( 1) GGCAGGAGAGGG 1 aldolase-a ( 147) GGCTGGGCAGGA 1 AchR_delta, ( 130) GGCGGGAGAGGG 1 Na-K ( 392) GGCTGGTGTGGG 1 ant1 ( 505) GGCTGGGCCGGG 1 acetylcholinesterase ( 102) GGCGGGGGCGGG 1 aB ( 277) GCCTGGGCAGGG 1 mhc_b ( 126) GGGAGGGGAGGA 1 Na-K ( 243) GGGAGGGGAGGA 1 ryanodine ( 298) AGGTGGGGTGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 9 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 14828 bayes= 10.7848 E= 1.2e+003 -89 -1081 159 -1081 -1081 -140 159 -1081 -1081 150 -82 -1081 -30 -1081 -82 169 -1081 -1081 176 -1081 -1081 -1081 176 -1081 -30 -1081 140 -189 -1081 -82 150 -1081 143 -82 -1081 43 -1081 -1081 176 -1081 -1081 -1081 176 -1081 11 -1081 140 -1081 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 9 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 18 E= 1.2e+003 0.111111 0.000000 0.888889 0.000000 0.000000 0.111111 0.888889 0.000000 0.000000 0.833333 0.166667 0.000000 0.166667 0.000000 0.166667 0.666667 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.166667 0.000000 0.777778 0.055556 0.000000 0.166667 0.833333 0.000000 0.555556 0.166667 0.000000 0.277778 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.222222 0.000000 0.777778 0.000000 -------------------------------------------------------------------------------- Time 671.47 secs. ******************************************************************************** ******************************************************************************** MOTIF 10 width = 12 sites = 15 llr = 169 E-value = 2.5e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif 10 Description -------------------------------------------------------------------------------- Simplified A :8:::5:311:: pos.-specific C a1a5a:::39a9 probability G ::::::a26::: matrix T :1:5:5:5:::1 bits 2.3 2.1 1.8 * * * * * 1.6 * * * * * Information 1.4 *** *** *** content 1.1 ******* *** (16.3 bits) 0.9 ******* *** 0.7 ******** *** 0.5 ************ 0.2 ************ 0.0 ------------ Multilevel CACTCAGTGCCC consensus C T AC sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 10 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ------------ ant1 - 39 1.01e-07 GATGTGTCTG CACTCAGTGCCC ACAGGAAAGA tnc + 74 3.45e-07 GACAGCCCTC CACCCAGTGCCC ATACAAGGCC neurofilament - 571 1.32e-06 ACCTCGCAGA CACCCTGTCCCC CCAACTCGCC Actin, + 481 1.32e-06 TGGAGCCAGC CACCCAGAGCCC GCTGCCGCCG AchR_gamma + 333 1.32e-06 TGTTATATGA CACCCAGAGCCC ATCTCTCTCT MLc1A - 177 1.96e-06 AGCTGAGAGC CACTCTGGGCCC TCAGCTCTGC McK_enh + 2 2.59e-06 C CACCCAGGGCCC CGTGGCTGCC McK_pro + 140 4.05e-06 GTTTCCCCTC CACTCAGTCCCT AGGAGGAAGG mhc_b - 92 4.48e-06 GCTTTGTCTG CACTCTGTCACC ACCCTGATCA ryanodine + 198 4.48e-06 AGAACTTCCC CACTCAGAGCCT CAGTCTGCCC tnI_frst_int + 87 4.48e-06 CCATACCCCT CCCTCTGTGCCC CAGCATGACA bin1 + 719 7.56e-06 CCCTCTCCCT CCCTCTGTCCCC GCGTCGCTCG MLc1/3_3f + 550 7.56e-06 GGGAGGACCC CACTCAGGGACC GGAGC McK_pro - 569 8.69e-06 GCACCATACC CACCCTGAACCC AGGCATGCTT McK_pro + 4 1.31e-05 ACC CTCCCTGTCCCC GCACAGCGAA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 10 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- ant1 1e-07 38_[-10]_666 tnc 3.5e-07 73_[+10]_225 neurofilament 1.3e-06 570_[-10]_447 Actin, 1.3e-06 480_[+10]_61 AchR_gamma 1.3e-06 332_[+10]_45 MLc1A 2e-06 176_[-10]_462 McK_enh 2.6e-06 1_[+10]_194 McK_pro 8.7e-06 3_[+10]_124_[+10]_417_[-10]_138 mhc_b 4.5e-06 91_[-10]_165 ryanodine 4.5e-06 197_[+10]_328 tnI_frst_int 4.5e-06 86_[+10]_99 bin1 7.6e-06 718_[+10]_156 MLc1/3_3f 7.6e-06 549_[+10]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 10 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 10 width=12 seqs=15 ant1 ( 39) CACTCAGTGCCC 1 tnc ( 74) CACCCAGTGCCC 1 neurofilament ( 571) CACCCTGTCCCC 1 Actin, ( 481) CACCCAGAGCCC 1 AchR_gamma ( 333) CACCCAGAGCCC 1 MLc1A ( 177) CACTCTGGGCCC 1 McK_enh ( 2) CACCCAGGGCCC 1 McK_pro ( 140) CACTCAGTCCCT 1 mhc_b ( 92) CACTCTGTCACC 1 ryanodine ( 198) CACTCAGAGCCT 1 tnI_frst_int ( 87) CCCTCTGTGCCC 1 bin1 ( 719) CCCTCTGTCCCC 1 MLc1/3_3f ( 550) CACTCAGGGACC 1 McK_pro ( 569) CACCCTGAACCC 1 McK_pro ( 4) CTCCCTGTCCCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 10 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 14828 bayes= 10.8918 E= 2.5e+004 -1055 176 -1055 -1055 196 -114 -1055 -162 -1055 176 -1055 -1055 -1055 67 -1055 137 -1055 176 -1055 -1055 137 -1055 -1055 118 -1055 -1055 176 -1055 37 -1055 -56 137 -162 18 103 -1055 -63 156 -1055 -1055 -1055 176 -1055 -1055 -1055 156 -1055 -63 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 10 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 15 E= 2.5e+004 0.000000 1.000000 0.000000 0.000000 0.800000 0.133333 0.000000 0.066667 0.000000 1.000000 0.000000 0.000000 0.000000 0.466667 0.000000 0.533333 0.000000 1.000000 0.000000 0.000000 0.533333 0.000000 0.000000 0.466667 0.000000 0.000000 1.000000 0.000000 0.266667 0.000000 0.200000 0.533333 0.066667 0.333333 0.600000 0.000000 0.133333 0.866667 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.866667 0.000000 0.133333 -------------------------------------------------------------------------------- Time 742.20 secs. ******************************************************************************** ******************************************************************************** MOTIF 11 width = 11 sites = 12 llr = 136 E-value = 1.9e+005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 11 Description -------------------------------------------------------------------------------- Simplified A ::::31:::2: pos.-specific C 3a2a49::18: probability G 7:::3::a9:: matrix T ::8:1:a:::a bits 2.3 * * 2.1 * * 1.8 * * ** * 1.6 *** ** * Information 1.4 *** **** * content 1.1 *** ****** (16.3 bits) 0.9 **** ****** 0.7 **** ****** 0.5 **** ****** 0.2 **** ****** 0.0 ----------- Multilevel GCTCCCTGGCT consensus C A sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 11 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ----------- Actin, + 303 4.89e-07 TGGTCTGGGG GCTCCCTGGCT GATCCTCTCC bin1 + 748 1.32e-06 TCGCTGGCTA GCTCGCTGGCT CGCTCGCCCG bin1 + 736 1.32e-06 TCCCCGCGTC GCTCGCTGGCT AGCTCGCTGG retinoblastoma + 177 1.32e-06 CTCCTCCACA GCTCGCTGGCT CCCGCCGCGG MLc1/3_3f - 535 1.81e-06 TGAGTGGGGT CCTCCCTGGCT GAGGCTTCCT Actin, - 150 3.32e-06 GGGTGTGGGT GCTCCCTGGAT GGTCTGTGGA myoglobin + 253 5.29e-06 AAGATTAGAC CCTCCCTGGAT GAGAGAGAGA cardiac - 172 5.29e-06 GCTGCCCCAG CCTCTCTGGCT CCACGGCCTT tnc - 140 5.29e-06 GCGTTATCTG GCCCCCTGGCT GCTAGTGCCG myoglobin - 305 6.60e-06 GACAAAGATC GCTCAATGGCT CGCTGTCCCC ant1 - 232 9.05e-06 CCCCACCAGA GCTCACTGCCT GGATATGGGC sm22-alpha - 124 1.06e-05 TGTCAGCCTC CCCCACTGGCT CGCTCCTCGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 11 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- Actin, 3.3e-06 149_[-11]_142_[+11]_240 bin1 1.3e-06 735_[+11]_1_[+11]_128 retinoblastoma 1.3e-06 176_[+11]_19 MLc1/3_3f 1.8e-06 534_[-11]_21 myoglobin 6.6e-06 252_[+11]_41_[-11]_58 cardiac 5.3e-06 171_[-11]_204 tnc 5.3e-06 139_[-11]_160 ant1 9.1e-06 231_[-11]_474 sm22-alpha 1.1e-05 123_[-11]_56 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 11 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 11 width=11 seqs=12 Actin, ( 303) GCTCCCTGGCT 1 bin1 ( 748) GCTCGCTGGCT 1 bin1 ( 736) GCTCGCTGGCT 1 retinoblastoma ( 177) GCTCGCTGGCT 1 MLc1/3_3f ( 535) CCTCCCTGGCT 1 Actin, ( 150) GCTCCCTGGAT 1 myoglobin ( 253) CCTCCCTGGAT 1 cardiac ( 172) CCTCTCTGGCT 1 tnc ( 140) GCCCCCTGGCT 1 myoglobin ( 305) GCTCAATGGCT 1 ant1 ( 232) GCTCACTGCCT 1 sm22-alpha ( 124) CCCCACTGGCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 11 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 11 n= 14874 bayes= 10.2744 E= 1.9e+005 -1023 18 118 -1023 -1023 176 -1023 -1023 -1023 -82 -1023 202 -1023 176 -1023 -1023 28 50 -23 -130 -130 164 -1023 -1023 -1023 -1023 -1023 228 -1023 -1023 176 -1023 -1023 -182 164 -1023 -30 150 -1023 -1023 -1023 -1023 -1023 228 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 11 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 11 nsites= 12 E= 1.9e+005 0.000000 0.333333 0.666667 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.833333 0.000000 1.000000 0.000000 0.000000 0.250000 0.416667 0.250000 0.083333 0.083333 0.916667 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.083333 0.916667 0.000000 0.166667 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- Time 812.08 secs. ******************************************************************************** ******************************************************************************** MOTIF 12 width = 8 sites = 9 llr = 97 E-value = 2.7e+005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 12 Description -------------------------------------------------------------------------------- Simplified A :::::::a pos.-specific C :4a:a::: probability G ::::::a: matrix T a6:a:a:: bits 2.3 * * * * 2.1 * * * * 1.8 * ****** 1.6 * ****** Information 1.4 * ****** content 1.1 ******** (15.5 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTCTCTGA consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 12 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- -------- sarcomeric - 867 9.41e-06 GCACTGCCCT TTCTCTGA AACGTAAAAG sarcomeric - 184 9.41e-06 TTCTCCTTCA TTCTCTGA AGGAGTTTCC aB - 418 9.41e-06 CCCACCCCTG TTCTCTGA AGCTGGTACA neurofilament - 746 9.41e-06 GGCCCTGATT TTCTCTGA GATCCCATGC tnI_up + 96 9.41e-06 GGCATTGTCT TTCTCTGA CTATAGGGTG mhc_b + 24 2.29e-05 TAGCAACTTT TCCTCTGA ACTACCGCTG sarcomeric + 252 2.29e-05 ACTCCTACAG TCCTCTGA GCATGAGTCG MLc1/3_3f - 104 2.29e-05 AGCAGGAGCA TCCTCTGA AGTGTACTGT MLc1/3_3f + 70 2.29e-05 GCCTTTTCAG TCCTCTGA ACTTTACCAT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 12 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- sarcomeric 2.3e-05 183_[-12]_60_[+12]_607_[-12]_52 aB 9.4e-06 417_[-12]_245 neurofilament 9.4e-06 745_[-12]_276 tnI_up 9.4e-06 95_[+12]_68 mhc_b 2.3e-05 23_[+12]_237 MLc1/3_3f 2.3e-05 69_[+12]_26_[-12]_455 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 12 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 12 width=8 seqs=9 sarcomeric ( 867) TTCTCTGA 1 sarcomeric ( 184) TTCTCTGA 1 aB ( 418) TTCTCTGA 1 neurofilament ( 746) TTCTCTGA 1 tnI_up ( 96) TTCTCTGA 1 mhc_b ( 24) TCCTCTGA 1 sarcomeric ( 252) TCCTCTGA 1 MLc1/3_3f ( 104) TCCTCTGA 1 MLc1/3_3f ( 70) TCCTCTGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 12 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 15012 bayes= 10.3618 E= 2.7e+005 -982 -982 -982 228 -982 59 -982 143 -982 176 -982 -982 -982 -982 -982 228 -982 176 -982 -982 -982 -982 -982 228 -982 -982 176 -982 228 -982 -982 -982 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 12 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 9 E= 2.7e+005 0.000000 0.000000 0.000000 1.000000 0.000000 0.444444 0.000000 0.555556 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- Time 881.23 secs. ******************************************************************************** ******************************************************************************** MOTIF 13 width = 12 sites = 14 llr = 156 E-value = 5.5e+005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 13 Description -------------------------------------------------------------------------------- Simplified A 5:a18:2229:3 pos.-specific C ::::::::2::1 probability G :a:9:6886:a6 matrix T 5:::24:::1:: bits 2.3 * 2.1 * 1.8 ** ** 1.6 ** * ** Information 1.4 *** * ** content 1.1 ***** ** ** (16.0 bits) 0.9 ******** ** 0.7 ******** ** 0.5 ************ 0.2 ************ 0.0 ------------ Multilevel AGAGAGGGGAGG consensus T TTAAA A sequence C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 13 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ------------ ryanodine - 424 3.42e-07 CATGCTGGAC AGAGATGGGAGG AAGTCCCCGC cytochrome + 240 3.42e-07 TGATTGGCCC AGAGAGGGGAGG TGACCCCAGG acetylcholinesterase + 47 3.42e-07 AGGGAGGGAG AGAGAGGGGAGG TGGCCACCCG MLc1A + 83 2.49e-06 TTTCATCCTG TGAGTTGGGAGG GTGTGGGGCA dystrophin_promoter + 71 3.64e-06 GAAACCAACT TGAGAGAGAAGG CGGGTCACTT ryanodine + 224 4.22e-06 CTGCCCTCTG TGAAATGGGAGA ATGATGGCAC aMPD3 - 153 5.17e-06 GCCCTTTAGG AGAGTGGGAAGG CTCAGAACAG neurofilament - 994 5.17e-06 GAGCCCGGAG AGAGAGGACAGG GGAGAGAGGG MLc1/3_3f - 348 5.58e-06 ACAGCCATAG TGAGATGGAAGC TGCCGGTACT sarcomeric + 731 6.17e-06 CTGGTACACC TGAGAGAAGAGA GAAACAAATC tnI_up + 46 7.02e-06 CCCCAACCCA TGAGATGACAGA CTATAATAGC MLc1A - 598 7.83e-06 GTCTGGGAGA TGAGATAGGAGC CTGGGCTGCC atrial + 78 1.04e-05 TGCAAGTGAC AGAATGGGGAGG GTTCTGTCTC AchR_gamma - 10 2.07e-05 CAGCGGCTCC AGAGAGGGCTGA GGTGGACTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 13 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- ryanodine 4.2e-06 223_[+13]_188_[-13]_102 cytochrome 3.4e-07 239_[+13]_49 acetylcholinesterase 3.4e-07 46_[+13]_182 MLc1A 7.8e-06 82_[+13]_503_[-13]_41 dystrophin_promoter 3.6e-06 70_[+13]_79 aMPD3 5.2e-06 152_[-13]_163 neurofilament 5.2e-06 993_[-13]_24 MLc1/3_3f 5.6e-06 347_[-13]_207 sarcomeric 6.2e-06 730_[+13]_184 tnI_up 7e-06 45_[+13]_114 atrial 1e-05 77_[+13]_139 AchR_gamma 2.1e-05 9_[-13]_368 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 13 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 13 width=12 seqs=14 ryanodine ( 424) AGAGATGGGAGG 1 cytochrome ( 240) AGAGAGGGGAGG 1 acetylcholinesterase ( 47) AGAGAGGGGAGG 1 MLc1A ( 83) TGAGTTGGGAGG 1 dystrophin_promoter ( 71) TGAGAGAGAAGG 1 ryanodine ( 224) TGAAATGGGAGA 1 aMPD3 ( 153) AGAGTGGGAAGG 1 neurofilament ( 994) AGAGAGGACAGG 1 MLc1/3_3f ( 348) TGAGATGGAAGC 1 sarcomeric ( 731) TGAGAGAAGAGA 1 tnI_up ( 46) TGAGATGACAGA 1 MLc1A ( 598) TGAGATAGGAGC 1 atrial ( 78) AGAATGGGGAGG 1 AchR_gamma ( 10) AGAGAGGGCTGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 13 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 14828 bayes= 10.9293 E= 5.5e+005 128 -1045 -1045 128 -1045 -1045 176 -1045 228 -1045 -1045 -1045 -53 -1045 154 -1045 193 -1045 -1045 6 -1045 -1045 96 106 6 -1045 142 -1045 6 -1045 142 -1045 6 -46 96 -1045 217 -1045 -1045 -153 -1045 -1045 176 -1045 47 -104 96 -1045 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 13 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 14 E= 5.5e+005 0.500000 0.000000 0.000000 0.500000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.142857 0.000000 0.857143 0.000000 0.785714 0.000000 0.000000 0.214286 0.000000 0.000000 0.571429 0.428571 0.214286 0.000000 0.785714 0.000000 0.214286 0.000000 0.785714 0.000000 0.214286 0.214286 0.571429 0.000000 0.928571 0.000000 0.000000 0.071429 0.000000 0.000000 1.000000 0.000000 0.285714 0.142857 0.571429 0.000000 -------------------------------------------------------------------------------- Time 950.40 secs. ******************************************************************************** ******************************************************************************** MOTIF 14 width = 11 sites = 9 llr = 104 E-value = 1.7e+006 ******************************************************************************** -------------------------------------------------------------------------------- Motif 14 Description -------------------------------------------------------------------------------- Simplified A ::2:::a:::1 pos.-specific C 9a:6aa:2aa: probability G :::1:::4::: matrix T 1:83:::3::9 bits 2.3 * 2.1 * 1.8 * *** *** 1.6 ** *** *** Information 1.4 *** *** *** content 1.1 *** *** *** (16.7 bits) 0.9 *** *** *** 0.7 ******* *** 0.5 *********** 0.2 *********** 0.0 ----------- Multilevel CCTCCCAGCCT consensus AT T sequence C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 14 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- ----------- enolase_b - 8 3.42e-07 CTTATTCCAC CCTCCCATCCT AAGAATC bin1 - 274 8.31e-07 CGCTCCGCCT CCTCCCAGCCT TCGGCCCTCG mhc_b + 202 1.41e-06 AAGCGGCCCT CCTTCCAGCCT CTCTTTATTT McK_pro + 81 1.90e-06 GTGACCACCG CCTCCCACCCT TGCCCTGAGT bin1 + 591 3.31e-06 CCGCGCGCGC CCATCCATCCT AGAAGGACCT neurofilament + 966 3.31e-06 CCGCACACAG CCATCCATCCT CCCCCTTCCC Actin, - 113 4.73e-06 CCTCCGCAGC CCTGCCAGCCT TGGGGACAAT McK_pro + 648 7.14e-06 GGGGACAACC CCTCCCAGCCA ATAGCACAGC cardiac - 70 8.55e-06 TCACACCGCC TCTCCCACCCT GCCATGGCCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 14 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- enolase_b 3.4e-07 7_[-14]_116 bin1 3.3e-06 273_[-14]_306_[+14]_285 mhc_b 1.4e-06 201_[+14]_56 McK_pro 7.1e-06 80_[+14]_556_[+14]_60 neurofilament 3.3e-06 965_[+14]_53 Actin, 4.7e-06 112_[-14]_430 cardiac 8.5e-06 69_[-14]_306 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 14 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 14 width=11 seqs=9 enolase_b ( 8) CCTCCCATCCT 1 bin1 ( 274) CCTCCCAGCCT 1 mhc_b ( 202) CCTTCCAGCCT 1 McK_pro ( 81) CCTCCCACCCT 1 bin1 ( 591) CCATCCATCCT 1 neurofilament ( 966) CCATCCATCCT 1 Actin, ( 113) CCTGCCAGCCT 1 McK_pro ( 648) CCTCCCAGCCA 1 cardiac ( 70) TCTCCCACCCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 14 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 11 n= 14874 bayes= 11.1374 E= 1.7e+006 -982 159 -982 -89 -982 176 -982 -982 11 -982 -982 192 -982 92 -140 69 -982 176 -982 -982 -982 176 -982 -982 228 -982 -982 -982 -982 -40 59 69 -982 176 -982 -982 -982 176 -982 -982 -89 -982 -982 211 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 14 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 11 nsites= 9 E= 1.7e+006 0.000000 0.888889 0.000000 0.111111 0.000000 1.000000 0.000000 0.000000 0.222222 0.000000 0.000000 0.777778 0.000000 0.555556 0.111111 0.333333 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.222222 0.444444 0.333333 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.111111 0.000000 0.000000 0.888889 -------------------------------------------------------------------------------- Time 1018.92 secs. ******************************************************************************** ******************************************************************************** MOTIF 15 width = 8 sites = 6 llr = 65 E-value = 1.3e+007 ******************************************************************************** -------------------------------------------------------------------------------- Motif 15 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C ::aa:::: probability G :::::aaa matrix T aa::a::: bits 2.3 ** * 2.1 ** * 1.8 ******** 1.6 ******** Information 1.4 ******** content 1.1 ******** (15.7 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTCCTGGG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 15 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Strand Start P-value Site ------------- ------ ----- --------- -------- bin1 + 454 1.92e-05 CTAGTCTCCT TTCCTGGG TTGCAGGAGA sarcomeric + 222 1.92e-05 TAGAAGGTTA TTCCTGGG GCTCCACCCC mlc-2 + 122 1.92e-05 GTATTTATTG TTCCTGGG CTGCAGAGAG cytochrome - 263 1.92e-05 CTCGCTCCCT TTCCTGGG GCCTGGGGTC aMPD3 + 32 1.92e-05 TGACCCATCC TTCCTGGG CTCTTCTCCC MLc1A + 41 1.92e-05 GTCTGTGGAG TTCCTGGG ATGCCTGCTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 15 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- bin1 1.9e-05 453_[+15]_425 sarcomeric 1.9e-05 221_[+15]_697 mlc-2 1.9e-05 121_[+15]_29 cytochrome 1.9e-05 262_[-15]_30 aMPD3 1.9e-05 31_[+15]_288 MLc1A 1.9e-05 40_[+15]_602 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 15 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 15 width=8 seqs=6 bin1 ( 454) TTCCTGGG 1 sarcomeric ( 222) TTCCTGGG 1 mlc-2 ( 122) TTCCTGGG 1 cytochrome ( 263) TTCCTGGG 1 aMPD3 ( 32) TTCCTGGG 1 MLc1A ( 41) TTCCTGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 15 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 15012 bayes= 11.2883 E= 1.3e+007 -923 -923 -923 228 -923 -923 -923 228 -923 176 -923 -923 -923 176 -923 -923 -923 -923 -923 228 -923 -923 176 -923 -923 -923 176 -923 -923 -923 176 -923 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 15 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 6 E= 1.3e+007 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- Time 1086.88 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- AChR_beta 5.20e-02 15_[-5(2.69e-05)]_53_[+5(1.34e-05)]_96 AchR_gamma 3.84e-06 9_[-13(2.07e-05)]_42_[+7(1.46e-05)]_65_[-14(5.76e-05)]_37_[-9(6.98e-07)]_14_[-7(1.20e-05)]_31_[+7(5.82e-07)]_35_[+9(4.11e-07)]_19_[+10(1.32e-06)]_45 AchR_delta, 9.07e-04 32_[-9(5.00e-05)]_61_[-2(4.58e-06)]_13_[-9(6.47e-06)]_29 AchR_epsilon 3.03e-04 66_[+9(1.34e-06)]_90_[-6(4.81e-05)]_18_[-2(9.14e-06)]_24_[+14(3.87e-05)]_41 Actin, 8.37e-13 17_[-5(1.34e-05)]_16_[-7(1.05e-05)]_60_[-14(4.73e-06)]_26_[-11(3.32e-06)]_18_[+9(1.30e-05)]_17_[-2(3.84e-05)]_18_[-9(2.19e-06)]_25_[-2(6.98e-07)]_18_[+11(4.89e-07)]_7_[-2(3.20e-05)]_73_[-2(2.39e-06)]_35_[-1(9.54e-05)]_5_[+8(2.41e-07)]_2_[+10(1.32e-06)]_48_[-9(5.62e-05)]_1 McK_enh 5.39e-04 1_[+10(2.59e-06)]_50_[+1(4.64e-05)]_103_[+1(2.22e-07)]_19 McK_pro 4.09e-05 3_[+10(1.31e-05)]_47_[+2(2.91e-05)]_7_[+14(1.90e-06)]_25_[+14(1.89e-05)]_12_[+10(4.05e-06)]_104_[+8(2.41e-07)]_36_[+2(4.83e-05)]_43_[-8(1.41e-07)]_120_[-7(1.96e-05)]_68_[-10(8.69e-06)]_11_[+2(6.41e-05)]_45_[+14(7.14e-06)]_20_[+1(4.64e-05)]_29 Desmin_enhancer, 9.66e-07 [-2(7.25e-06)]_45_[+1(2.62e-06)]_24_[-5(1.34e-05)]_27 Desmin_promoter 4.53e-03 53_[+11(1.25e-05)]_94_[+2(9.63e-06)]_134 glut4 1.21e-02 14_[+1(8.21e-08)]_36 myogenin 9.65e-09 6_[+9(3.54e-06)]_13_[+3(1.23e-05)]_34_[+5(1.34e-05)]_12_[-7(7.58e-06)]_8_[-1(1.11e-05)]_159 MLc1/3_3f 6.88e-09 69_[+12(2.29e-05)]_26_[-12(2.29e-05)]_133_[+4(1.57e-05)]_19_[+4(1.57e-05)]_68_[-13(5.58e-06)]_31_[+1(8.21e-08)]_17_[-3(4.52e-05)]_8_[+3(3.93e-05)]_27_[+7(5.05e-05)]_2_[-7(4.00e-05)]_16_[+3(1.57e-06)]_5_[-11(1.81e-06)]_4_[+10(7.56e-06)]_5 MLc1/3 4.39e-04 17_[+3(3.99e-06)]_17_[-1(3.27e-05)]_47_[+1(8.36e-07)]_12 MLc1A 4.98e-09 40_[+15(1.92e-05)]_34_[+13(2.49e-06)]_30_[-5(1.34e-05)]_5_[+11(2.29e-05)]_28_[-10(1.96e-06)]_65_[+1(4.19e-07)]_2_[-2(2.43e-05)]_40_[+11(8.96e-05)]_107_[+2(6.98e-07)]_60_[-1(2.02e-05)]_7_[-5(2.69e-05)]_44_[+3(1.86e-05)]_9_[-13(7.83e-06)]_41 tnc 1.34e-05 73_[+10(3.45e-07)]_54_[-11(5.29e-06)]_11_[+11(3.35e-05)]_44_[+1(3.37e-07)]_83 tnI_up 1.69e-05 3_[+10(2.99e-05)]_30_[+13(7.02e-06)]_38_[+12(9.41e-06)]_34_[+1(1.81e-06)]_23 tnI_frst_int 7.56e-06 9_[+1(3.27e-05)]_66_[+10(4.48e-06)]_35_[-2(3.20e-05)]_[-9(1.34e-06)]_3_[-9(3.41e-05)]_9_[+2(2.53e-05)]_6 tnI_prom 3.54e-06 19_[+6(2.16e-06)]_[-1(8.37e-06)]_4_[-5(2.69e-05)]_54 myosin_b 7.74e-07 [-9(4.33e-06)]_42_[+8(3.00e-06)]_5_[+10(5.71e-05)]_18 cardiac 1.40e-08 8_[-6(3.48e-05)]_24_[+3(4.52e-05)]_14_[-14(8.55e-06)]_25_[-7(2.79e-06)]_38_[+1(2.98e-06)]_6_[-11(5.29e-06)]_75_[+3(2.59e-05)]_12_[+2(3.20e-05)]_34_[+2(3.84e-05)]_49 skeletal 7.84e-03 32_[+2(2.18e-05)]_81_[+1(1.11e-05)]_15 VSM 6.93e-01 98 acetylcholinesterase 7.76e-05 35_[+2(6.84e-05)]_[+13(3.42e-07)]_12_[+13(5.64e-05)]_[+9(1.91e-05)]_7_[+9(9.81e-06)]_21_[+6(8.15e-06)]_61_[-2(8.43e-05)]_23 neurofilament 2.15e-15 42_[-7(4.24e-05)]_92_[-6(3.81e-06)]_38_[+3(3.09e-05)]_40_[+1(9.02e-05)]_35_[+6(2.85e-07)]_1_[+6(7.37e-07)]_48_[+3(6.89e-08)]_[+4(3.23e-06)]_7_[+3(1.88e-06)]_13_[+7(1.16e-06)]_[+4(1.57e-05)]_42_[-4(3.23e-06)]_47_[+3(6.56e-06)]_27_[-10(1.32e-06)]_19_[+7(1.10e-05)]_73_[-14(5.28e-05)]_20_[+3(1.88e-06)]_17_[-12(9.41e-06)]_96_[-8(1.35e-06)]_63_[+1(2.40e-05)]_30_[+14(3.31e-06)]_3_[-13(8.21e-07)]_2_[-13(5.17e-06)]_24 aMPD3 2.20e-05 31_[+15(1.92e-05)]_82_[-10(3.53e-05)]_2_[+6(5.17e-06)]_6_[-13(5.17e-06)]_41_[-1(4.64e-05)]_93_[+2(8.43e-05)]_7 aB 1.49e-07 87_[+4(7.40e-05)]_8_[-1(2.57e-05)]_162_[-9(1.40e-05)]_46_[+2(1.91e-05)]_14_[+14(2.60e-05)]_47_[-12(9.41e-06)]_1_[+2(2.39e-06)]_20_[+7(1.16e-06)]_48_[-3(1.34e-05)]_12_[+6(5.41e-05)]_119 cytochrome 8.52e-07 5_[-4(6.45e-06)]_4_[-7(1.46e-05)]_47_[+1(1.33e-05)]_51_[-7(5.87e-06)]_12_[-11(8.96e-05)]_7_[+1(7.66e-06)]_5_[+1(5.04e-06)]_34_[+13(3.42e-07)]_11_[-15(1.92e-05)]_30 ventrical/slow 1.81e-04 18_[+6(1.56e-06)]_15_[+6(2.85e-07)]_1_[+6(4.02e-07)]_31_[-2(1.03e-05)]_67_[-9(2.84e-06)]_60_[+2(5.54e-05)]_54 mlc-2 1.45e-07 26_[+2(3.20e-05)]_50_[-1(8.36e-07)]_15_[-4(2.67e-05)]_[+15(1.92e-05)]_3_[+7(4.10e-06)]_15 myoglobin 2.22e-06 123_[-2(6.26e-06)]_19_[-2(4.83e-05)]_40_[+1(4.02e-05)]_20_[+3(8.21e-06)]_5_[+11(5.29e-06)]_9_[+3(9.98e-06)]_3_[+2(6.98e-07)]_6_[-11(6.60e-06)]_58 PgaM-M 1.68e-05 15_[-1(6.73e-07)]_30_[-2(1.37e-05)]_53_[+9(4.11e-07)]_58 retinoblastoma 1.00e-04 53_[+9(2.19e-06)]_29_[-4(2.21e-05)]_74_[+11(1.32e-06)]_19 ryanodine 6.22e-05 129_[-1(3.28e-06)]_57_[+10(4.48e-06)]_14_[+13(4.22e-06)]_62_[-9(1.83e-05)]_114_[-13(3.42e-07)]_82_[-2(1.17e-05)]_9 SERca2 5.84e-01 124_[+2(2.18e-05)]_3_[+2(4.58e-06)]_42 sarcomeric 1.64e-09 8_[+3(1.86e-05)]_[-4(2.21e-05)]_13_[+1(1.45e-05)]_72_[+3(9.98e-06)]_2_[-1(1.11e-05)]_16_[+4(1.57e-05)]_10_[-12(9.41e-06)]_30_[+15(1.92e-05)]_22_[+12(2.29e-05)]_23_[+3(3.09e-05)]_22_[+7(9.43e-05)]_75_[-1(9.08e-06)]_35_[-1(3.37e-07)]_26_[+9(4.30e-05)]_48_[+7(7.58e-06)]_35_[-14(4.91e-05)]_5_[-2(4.83e-05)]_18_[+8(8.04e-07)]_2_[+8(4.46e-06)]_68_[+13(6.17e-06)]_1_[+4(1.57e-05)]_32_[+14(4.34e-05)]_72_[-12(9.41e-06)]_9_[+1(4.30e-05)]_32 Na-K 9.85e-08 17_[+3(4.86e-05)]_43_[+8(1.35e-06)]_38_[-2(2.18e-05)]_96_[-8(2.90e-06)]_1_[+9(1.50e-05)]_36_[+2(2.43e-05)]_4_[+2(3.47e-05)]_9_[-1(6.38e-06)]_5_[-5(1.34e-05)]_42_[+9(7.16e-06)]_17 sm22-alpha 3.60e-05 16_[-7(4.45e-05)]_28_[-10(3.21e-05)]_4_[+2(2.02e-05)]_41_[-11(1.06e-05)]_38_[+14(2.06e-05)]_7 aldolase-a 4.06e-06 11_[-2(2.53e-05)]_17_[+6(2.27e-06)]_18_[+1(7.66e-06)]_28_[+2(6.84e-05)]_28_[+9(4.62e-06)]_29_[+11(5.86e-05)]_80 atrial 1.33e-04 19_[+1(8.47e-05)]_47_[+13(1.04e-05)]_24_[+2(2.43e-05)]_1_[+1(1.92e-06)]_41_[+3(3.37e-05)]_39 dystrophin_intron 6.95e-04 15_[+3(9.98e-06)]_5_[+3(7.31e-06)]_39_[+3(8.21e-06)]_1_[+1(1.72e-05)]_11_[+4(7.40e-05)]_42_[+7(5.82e-07)]_16 dystrophin_promoter 9.35e-03 70_[+13(3.64e-06)]_54_[+7(2.52e-05)]_14 myo-D 1.66e-05 64_[+8(5.93e-05)]_23_[+7(8.21e-07)]_54_[+2(1.70e-06)]_83 ant1 9.36e-09 38_[-10(1.01e-07)]_53_[+3(1.02e-06)]_61_[+13(3.84e-05)]_43_[-11(9.05e-06)]_25_[+3(1.56e-05)]_119_[+1(1.23e-05)]_95_[-9(8.57e-06)]_43_[+2(4.58e-06)]_3_[-9(3.41e-05)]_131 enolase_b 4.08e-07 7_[-14(3.42e-07)]_23_[+2(1.70e-06)]_36_[-1(1.81e-06)]_35 bin1 2.56e-08 149_[+4(6.45e-06)]_116_[-14(8.31e-07)]_120_[-3(1.34e-05)]_37_[+15(1.92e-05)]_129_[+14(3.31e-06)]_35_[+1(3.01e-05)]_54_[-2(3.47e-05)]_6_[+10(7.56e-06)]_5_[+11(1.32e-06)]_1_[+11(1.32e-06)]_93_[+2(1.37e-05)]_24 mhc_b 5.46e-09 23_[+12(2.29e-05)]_60_[-10(4.48e-06)]_22_[+9(1.50e-05)]_15_[-3(7.31e-06)]_37_[+14(1.41e-06)]_3_[-1(1.25e-06)]_13_[-3(1.57e-06)]_17 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 15 reached. ******************************************************************************** CPU: bionode ********************************************************************************